[HTML][HTML] Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

…, HM Morrison, V Karalis, JYJ Chung, KJ Chen… - Nature …, 2020 - nature.com
The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon
recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of …

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

DX Ji, LH Yamashiro, KJ Chen, N Mukaida… - Nature …, 2019 - nature.com
The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is responsible for
more human mortality than any other single pathogen 1 . Progression to active disease …

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

…, DI Kotov, SR Margolis, A Louie, V Chevée, KJ Chen… - Elife, 2021 - elifesciences.org
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective
immune responses during bacterial infections. An important question is how type I IFNs are …

[HTML][HTML] An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses

…, X Kang, KS Chen, T Jehng, L Jones, J Chen… - Nature …, 2020 - nature.com
Oncolytic viruses offer an in situ vaccination approach to activate tumor-specific T cell responses.
However, the upregulation of PD-L1 expression on tumor cells and immune cells leads …

Echo planar time‐resolved imaging (EPTI)

…, B Bilgic, M Katherine Manhard, J Chen… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose To develop an efficient distortion‐ and blurring‐free multi‐shot EPI technique for
time‐resolved multiple‐contrast and/or quantitative imaging. Methods EPI is a commonly used …

Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration

…, B Levy, O Nahum, J Chen, K Chen… - Cancer biology & …, 2016 - Taylor & Francis
Malignant mesothelioma (MM) is an aggressive tumor arising from mesothelial linings of the
serosal cavities. Pleural space is the most common site, accounting for about 80% of cases, …

Analysis of simultaneous radiative and conductive heat transfer in fluidized beds

JC CHEN, KL CHEN - Chemical Engineering Communications, 1981 - Taylor & Francis
… Ozkaynak and Chen" obtained experimental evidence that the density of packets at the
surface of heat transfer tubes, in bubbling fluidized beds, approach the density of packed beds. It …

Bounded relationality: how intermediary organizations encourage consumer exchanges with routinized relational work in a social insurance market

KK Chen - Socio-Economic Review, 2020 - academic.oup.com
Using observations of US governmental, advocacy and human service organizations’ (GAHSOs)
talks, I show how these intermediary organizations endorsed ‘bounded relationality’ …

[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

…, DS Atri, J Beechem, OR Brook, J Chen… - Nature, 2021 - nature.com
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

JJ Tyson, KC Chen, B Novak - Current opinion in cell biology, 2003 - Elsevier
The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …