[HTML][HTML] Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
…, HM Morrison, V Karalis, JYJ Chung, KJ Chen… - Nature …, 2020 - nature.com
The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon
recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of …
recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of …
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
DX Ji, LH Yamashiro, KJ Chen, N Mukaida… - Nature …, 2019 - nature.com
The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis and is responsible for
more human mortality than any other single pathogen 1 . Progression to active disease …
more human mortality than any other single pathogen 1 . Progression to active disease …
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
…, DI Kotov, SR Margolis, A Louie, V Chevée, KJ Chen… - Elife, 2021 - elifesciences.org
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective
immune responses during bacterial infections. An important question is how type I IFNs are …
immune responses during bacterial infections. An important question is how type I IFNs are …
[HTML][HTML] An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses
…, X Kang, KS Chen, T Jehng, L Jones, J Chen… - Nature …, 2020 - nature.com
Oncolytic viruses offer an in situ vaccination approach to activate tumor-specific T cell responses.
However, the upregulation of PD-L1 expression on tumor cells and immune cells leads …
However, the upregulation of PD-L1 expression on tumor cells and immune cells leads …
Echo planar time‐resolved imaging (EPTI)
Purpose To develop an efficient distortion‐ and blurring‐free multi‐shot EPI technique for
time‐resolved multiple‐contrast and/or quantitative imaging. Methods EPI is a commonly used …
time‐resolved multiple‐contrast and/or quantitative imaging. Methods EPI is a commonly used …
Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration
…, B Levy, O Nahum, J Chen, K Chen… - Cancer biology & …, 2016 - Taylor & Francis
Malignant mesothelioma (MM) is an aggressive tumor arising from mesothelial linings of the
serosal cavities. Pleural space is the most common site, accounting for about 80% of cases, …
serosal cavities. Pleural space is the most common site, accounting for about 80% of cases, …
Analysis of simultaneous radiative and conductive heat transfer in fluidized beds
JC CHEN, KL CHEN - Chemical Engineering Communications, 1981 - Taylor & Francis
… Ozkaynak and Chen" obtained experimental evidence that the density of packets at the
surface of heat transfer tubes, in bubbling fluidized beds, approach the density of packed beds. It …
surface of heat transfer tubes, in bubbling fluidized beds, approach the density of packed beds. It …
Bounded relationality: how intermediary organizations encourage consumer exchanges with routinized relational work in a social insurance market
KK Chen - Socio-Economic Review, 2020 - academic.oup.com
Using observations of US governmental, advocacy and human service organizations’ (GAHSOs)
talks, I show how these intermediary organizations endorsed ‘bounded relationality’ …
talks, I show how these intermediary organizations endorsed ‘bounded relationality’ …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
The physiological responses of cells to external and internal stimuli are governed by genes
and proteins interacting in complex networks whose dynamical properties are impossible to …
and proteins interacting in complex networks whose dynamical properties are impossible to …