As reliable, efficient genome sequencing becomes ubiquitous, the need for similarly reliable
and efficient variant calling becomes increasingly important. The Genome Analysis Toolkit (…

The changing landscape of genomics research and clinical practice has created a need for
computational pipelines capable of efficiently orchestrating complex analysis stages while …

Background Use of the Genome Analysis Toolkit (GATK) continues to be the standard practice
in genomic variant calling in both research and the clinic. Recently the toolkit has been …

Bioinformatics research is frequently performed using complex workflows with multiple steps,
fans, merges, and conditionals. This complexity makes management of the workflow …

As reliable, efficient genome sequencing becomes more ubiquitous, the need for similarly
reliable and efficient variant calling becomes increasingly important. The Genome Analysis …

The author offers observation on the dirt roads in the metropolis of Ann Arbor, Michigan. She
reveals how her father described the potholes on Warner Road. The author describes the …

… My husband, Chris Kendig, kept the household afloat while I was buried in books, accepted
… , Joan Dolan, Tom, Suzanne, and Katie Kendig, the BARCC alumnae brunch crew, the …

Geographic Information Science (GIS) is an interdisciplinary science aiming to detect and
visually represent patterns in spatial data. GIS is used by businesses to determine where to …

The idea that science is or should be value-free, and that values are or should be formed
independently of science, has been under fire by philosophers of science for decades. Science …

In this thesis I present a critical examination of the role played by mechanistic ideas in shaping
our understanding of living systems. I draw on a combination of historical, philosophical, …