[HTML][HTML] MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

…, EL Ryder, SY Lee, CW Wasson, KL Harper… - PLoS …, 2020 - journals.plos.org
Human papillomaviruses (HPV) are a major cause of malignancy worldwide. They are the
aetiological agents of almost all cervical cancers as well as a sub-set of other anogenital and …

[HTML][HTML] CircRNAs: From anonymity to novel regulators of gene expression in cancer

KL Harper, E Mcdonnell… - … journal of oncology, 2019 - spandidos-publications.com
Circular RNAs (circRNAs) are a group of non‑coding RNAs, formed mostly through a unique
backsplicing mechanism. Originally proposed to be a by‑product from errors in splicing, …

Dysregulation of the miR‐30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication

KL Harper, TJ Mottram, CA Anene, B Foster… - EMBO …, 2022 - embopress.org
Non‐coding RNA (ncRNA) regulatory networks are emerging as critical regulators of gene
expression. These intricate networks of ncRNA:ncRNA interactions modulate multiple cellular …

[HTML][HTML] m6A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication

…, TJ Mottram, ID Yonchev, CJ Trevelyan, KL Harper… - Viruses, 2023 - mdpi.com
The epitranscriptomic modification N 6 -methyladenosine (m 6 A) is a ubiquitous feature of
the mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory …

Thin-layer chromatographic system for identification and quantitation of potato tuber glycoalkaloids

LS Cadle, DA Stelzig, KL Harper… - Journal of Agricultural …, 1978 - ACS Publications
RESULTS AND DISCUSSION The levels of total glycoalkaloids in the tubers of three potato
cultivare are shown in Table I. The amounts of-solanine and-chaconine, the only …

Pseudouridine prevalence in Kaposi's sarcoma-associated herpesvirus transcriptome reveals an essential mechanism for viral replication

TJ Mottram, KL Harper, EJR Vasconcelos, CA Anene… - bioRxiv, 2023 - biorxiv.org
Pseudouridylation is a prevalent RNA modification shown to occur in tRNAs, rRNAs, snoRNAs
and most recently mRNAs and lncRNAs. Emerging evidence suggests that this dynamic …

[HTML][HTML] Kaposi's sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs

…, EJR Vasconcelos, TJ Mottram, KL Harper… - Nature …, 2023 - nature.com
Historically, ribosomes were viewed as unchanged homogeneous macromolecular
machines with no regulatory capacity for mRNA translation. An emerging concept is that …

CircHIPK3 dysregulation of the miR-30c/DLL4 axis is essential for KSHV lytic replication

KL Harper, TJ Mottram, CA Anene, B Foster… - bioRxiv, 2021 - biorxiv.org
Non-coding RNA (ncRNA) regulatory networks are emerging as critical regulators of gene
expression. These intricate networks of ncRNA:ncRNA interactions modulate multiple cellular …

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

…, S Henderson, R Motallebzadeh, AD Salama, L Harper… - The Lancet, 2021 - thelancet.com
We sought to compare neutralising antibody responses between seronaive haemodialysis
patients and the healthy individuals we have already reported on as part of the Legacy study. …

[HTML][HTML] Insights into the evolving roles of circular RNAs in cancer

KL Harper, TJ Mottram, A Whitehouse - Cancers, 2021 - mdpi.com
Simple Summary The central dogma of RNA biology was traditionally governed by the
transcription of DNA into messenger RNA (mRNA) followed by translation into protein. As …