A glucose-starvation response governs endocytic trafficking and eisosomal retention of surface cargoes in budding yeast

…, DD Bisinski, S Shashkova, KM Paine… - Journal of cell …, 2021 - journals.biologists.com
Eukaryotic cells adapt their metabolism to the extracellular environment. Downregulation of
surface cargo proteins in response to nutrient stress reduces the burden of anabolic …

[HTML][HTML] The phosphatase Glc7 controls the eisosomal response to starvation via post-translational modification of Pil1

KM Paine, KME Laidlaw, GJO Evans… - Journal of Cell …, 2023 - journals.biologists.com
The yeast (Saccharomyces cerevisiae) plasma membrane (PM) is organised into specific
subdomains that regulate surface membrane proteins. Surface transporters actively uptake …

Fur4‐mediated uracil‐scavenging to screen for surface protein regulators

KM Paine, GB Ecclestone, C MacDonald - Traffic, 2021 - Wiley Online Library
Cell surface membrane proteins perform diverse and critical functions and are spatially and
temporally regulated by membrane trafficking pathways. Although perturbations in these …

[HTML][HTML] The Rpd3-complex regulates expression of multiple cell surface recycling factors in yeast

K Amoiradaki, KR Bunting, KM Paine, JE Ayre… - International Journal of …, 2021 - mdpi.com
Intracellular trafficking pathways control residency and bioactivity of integral membrane proteins
at the cell surface. Upon internalisation, surface cargo proteins can be delivered back to …

Endosomal cargo recycling mediated by Gpa1 and phosphatidylinositol 3-kinase is inhibited by glucose starvation

KME Laidlaw, KM Paine, DD Bisinski… - Molecular biology of …, 2022 - Am Soc Cell Biol
Cell surface protein trafficking is regulated in response to nutrient availability, with multiple
pathways directing surface membrane proteins to the lysosome for degradation in response …

[PDF][PDF] Endosomal recycling to the surface mediated by Gpa1 and PI3-Kinase is inhibited by glucose starvation

KME Laidlaw, KM Paine, DD Bisinski, G Calder… - Biorxiv, 2021 - academia.edu
Cell surface protein trafficking is regulated in response to nutrient availability, with multiple
pathways directing surface membrane proteins to the lysosome for degradation in response …

Target coping strategies for interventions aimed at maximizing psychosocial adjustment in people with multiple sclerosis

…, KM Kirby, E Butler, M Paine… - … Journal of MS care, 2018 - meridian.allenpress.com
Background: The experience of psychological distress is prevalent in people with multiple
sclerosis (MS), including high levels of stress, anxiety, and depression. It has been shown that …

Coping mediates and moderates the relationship between executive functions and psychological adjustment in multiple sclerosis.

…, LA Kiropoulos, KM Kirby, E Butler, M Paine… - …, 2016 - psycnet.apa.org
Objective: To identify the moderating and mediating relationship of different coping strategies
between executive function and stress, depression and anxiety in people with multiple …

The effect of executive function on stress, depression, anxiety, and quality of life in multiple sclerosis

…, KM Kirby, E Butler, M Paine… - Journal of clinical and …, 2015 - Taylor & Francis
The experience of cognitive deficits and emotional dysfunction are prevalent in people with
multiple sclerosis (PwMS), although research examining their interaction has provided …

Executive function is an important consideration for coping strategy use in people with multiple sclerosis

…, KM Kirby, E Butler, M Paine… - Journal of clinical and …, 2017 - Taylor & Francis
Introduction: Executive function deficits are prevalent in people with multiple sclerosis (PwMS),
and PwMS use less adaptive coping than healthy controls. This cross-sectional study …