High-fidelity intracranial electrode arrays for recording and stimulating brain activity have
facilitated major advances in the treatment of neurological conditions over the past decade. …

Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to
vision impairment. Development of cell therapy requires a better understanding of the signals …

Glaucoma, the worldwide leading cause of irreversible blindness, is characterized by
progressive degeneration of the optic nerve and loss of retinal ganglion cells. Research into …

The lentivirus system enables efficient genetic modification of both dividing and non‐dividing
cells and therefore is a useful tool for elucidating developmental processes and disease …

Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for
development of regenerative medicine, disease modeling, and drug discovery. However, the …

Effective communication requires reliable signals and competent receptors. Theoretical and
empirical accounts of animal signaling focus overwhelmingly on the capacity of the signaler …

The differentiation of patient-specific induced pluripotent stem cells (iPSCs) into specific
neuronal subtypes has been exploited as an approach for modeling a variety of neurological …

We demonstrate that a combination of Noggin, Dickkopf-1, Insulin Growth Factor 1 and basic
Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into …

Social insect colonies exhibit highly coordinated responses to ecological challenges by
acquiring information that is disseminated throughout the colony. Some responses are …

Gene editing in human embryonic stem cells (hESCs) has been significantly enhanced by
the discovery and development of CRISPR Cas9, a programmable nuclease system that can …