User profiles for Katherine S Ruth
 | Katherine RuthLecturer in Clinical and Biomedical Sciences, University of Exeter Verified email at exeter.ac.uk Cited by 6996 |
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
[HTML][HTML] Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …
Genome-wide associations for birth weight and correlations with adult disease
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …
observational studies is reproducibly associated with future risk of adult metabolic diseases …
Using human genetics to understand the disease impacts of testosterone in men and women
Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …
health and body composition, yet its effects on disease outcomes are unknown. To better …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Genetic insights into biological mechanisms governing human ovarian ageing
Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …
, but insights into its underlying biological mechanisms and treatments to preserve it are …
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …
[HTML][HTML] Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci
Disrupted circadian rhythms and reduced sleep duration are associated with several human
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …
diseases, particularly obesity and type 2 diabetes, but until recently, little was known about …
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
Objective To determine whether height and body mass index (BMI) have a causal role in
five measures of socioeconomic status. Design Mendelian randomisation study to test for …
five measures of socioeconomic status. Design Mendelian randomisation study to test for …
[HTML][HTML] Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer
data from 85,670 UK Biobank participants, we perform a genome-wide association …
data from 85,670 UK Biobank participants, we perform a genome-wide association …