[HTML][HTML] TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA
replication and transcription. TOP1 is also a major driver of endogenous genome instability, …
replication and transcription. TOP1 is also a major driver of endogenous genome instability, …
[HTML][HTML] Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors
…, LJ Bawden, R Figueiredo, R Tawar, K Wiseman… - JCI insight, 2021 - ncbi.nlm.nih.gov
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There
is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but …
is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but …
[HTML][HTML] SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
…, B Vaz, J Oehler, D Pilger, D Lessel, K Wiseman… - Nature …, 2019 - nature.com
The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA
replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced …
replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced …
[HTML][HTML] Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication
Genome amplification (DNA synthesis) is one of the most demanding cellular processes in
all proliferative cells. The DNA replication machinery (also known as the replisome) …
all proliferative cells. The DNA replication machinery (also known as the replisome) …
A large patient study confirming that facioscapulohumeral muscular dystrophy (FSHD) disease expression is almost exclusively associated with an FSHD locus …
NST Thomas, K Wiseman, G Spurlock… - Journal of medical …, 2007 - jmg.bmj.com
Facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant disorder,
represents the third most common human muscular dystrophy. The FSHD disease locus, at …
represents the third most common human muscular dystrophy. The FSHD disease locus, at …
[PDF][PDF] E-quipped to serve: delivering holistic Christian mission training through e-learning
LK Wiseman - 2015 - pstorage-loughborough-53465.s3 …
Developments in Information and Communication Technologies are rapidly breaking down
the barriers of time and place that may have previously limited learning to those able to …
the barriers of time and place that may have previously limited learning to those able to …
[PDF][PDF] β-cell targeted Immune Suppressive PD-1 Bispecific Agonists-a Novel Approach to Treat Type 1 Diabetes
…, L Bawden, E Henderson, R Figueiredo, K Wiseman… - Target, 2021 - npod.org
• The success of immunosuppressive therapies in protecting pancreatic islets from destruction
by autoreactive T cells and treat Type 1 Diabetes (T1D) has, so far, been limited either due …
by autoreactive T cells and treat Type 1 Diabetes (T1D) has, so far, been limited either due …
Characterisation of a New p97 Adaptor in Genome Stability
K Wiseman - 2017 - ora.ox.ac.uk
Cells are subjected to constant genotoxic stress arising from both endogenous and exogenous
sources which can drive the development of a wide range of diseases, especially cancers…
sources which can drive the development of a wide range of diseases, especially cancers…
[CITATION][C] Minding the money: Governance of climate change adaptation finance in Nepal
K Wiseman, RP Chhetri - Oxfam Policy …, 2011 - Oxfam in association with GSE …
[CITATION][C] Speaking of oneself: Self-consciousness and the first-person prounoun
RK Wiseman - 2010 - The University of York