Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's disease (PD).
To better understand the link between mutant LRRK2 and PD pathology, we derived …

Importance While mutations in glucocerebrosidase (GBA1) are associated with an increased
risk for Parkinson disease (PD), it is important to establish whether such mutations are also …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

Background Parkinson's disease (PD) patients with GBA mutations show an earlier age at
onset and more severe non‐motor symptoms compared with PD patients without GBA …

Objective Quantification of gait with wearable technology is promising; recent cross‐sectional
studies showed that gait characteristics are potential prodromal markers for Parkinson …

Importance Substantial genome-wide association study (GWAS) work in Parkinson disease (PD)
has led to the discovery of an increasing number of loci shown reliably to be associated …

There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent
research in murine models suggests that parkin and PINK1 deficiency leads to impaired …

Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD),
often observed early in the course of the disease. We hypothesized that subtle changes in …