User profiles for Kathrin Ulrich

Kathrin Ulrich

Jun-Prof. of Cellular Biochemistry, Institute of Biochemistry, University of Cologne
Verified email at uni-koeln.de
Cited by 768

The role of thiols in antioxidant systems

K Ulrich, U Jakob - Free Radical Biology and Medicine, 2019 - Elsevier
The sulfur biochemistry of the thiol group endows cysteines with a number of highly specialized
and unique features that enable them to serve a variety of different functions in the cell. …

Developmental ROS individualizes organismal stress resistance and lifespan

D Bazopoulou, D Knoefler, Y Zheng, K Ulrich… - Nature, 2019 - nature.com
A central aspect of aging research concerns the question of when individuality in lifespan
arises 1 . Here we show that a transient increase in reactive oxygen species (ROS), which …

[HTML][HTML] Thiol-based switching mechanisms of stress-sensing chaperones

K Ulrich, B Schwappach, U Jakob - Biological Chemistry, 2021 - degruyter.com
Thiol-based redox switches evolved as efficient post-translational regulatory mechanisms
that enable individual proteins to rapidly respond to sudden environmental changes. While …

[PDF][PDF] From guide to guard—activation mechanism of the stress-sensing chaperone Get3

K Ulrich, Á Farkas, O Chan, O Katamanin… - Molecular cell, 2022 - cell.com
Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and
potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved …

Effectiveness of an intensive multidisciplinary headache treatment program

…, E Lang, B Muehlhans, R Sittl, K Ulrich - … : The Journal of …, 2009 - Wiley Online Library
Objective.— To investigate if the effectiveness of a 96‐hour multidisciplinary headache
treatment program exceeds the effectiveness of a 20‐hour program and primary care. …

Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of Neglected Tropical Diseases (NTDs)

…, A Wagner, UA Hellmich, K Ulrich… - Journal of Medicinal …, 2017 - ACS Publications
This paper describes the development of a class of peptide-based inhibitors as novel
antitrypanosomal and antimalarial agents. The inhibitors are based on a characteristic peptide …

Escherichia coli RclA is a highly active hypothiocyanite reductase

JD Meredith, I Chapman, K Ulrich… - Proceedings of the …, 2022 - National Acad Sciences
Hypothiocyanite and hypothiocyanous acid (OSCN − /HOSCN) are pseudohypohalous
acids released by the innate immune system which are capable of rapidly oxidizing sulfur-…

Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes—A Quantitative Redox Proteome and Thiol Analysis

K Ulrich, C Finkenzeller, S Merker, F Rojas… - Antioxidants & Redox …, 2017 - liebertpub.com
Kathrin UlrichKathrin Ulrich, Caroline Finkenzeller, Sabine Merker, Federico Rojas,
Keith Matthews, Thomas Ruppert, and R. Luise Krauth-Siegel.Stress-Induced Protein S-…

[HTML][HTML] An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

RB Currier, K Ulrich, AE Leroux, N Dirdjaja… - PLoS …, 2019 - journals.plos.org
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly
conserved cysteine residues to catalyze thiol-disulfide exchange reactions. Here we …

[HTML][HTML] A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

…, T Schmenger, N Dirdjaja, M Bonilla, B Manta, K Ulrich… - Redox Biology, 2018 - Elsevier
Trypanosoma brucei glutaredoxin 2 (Grx2) is a dithiol glutaredoxin that is specifically located
in the mitochondrial intermembrane space. Bloodstream form parasites lacking Grx2 or both…