The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …

Radiation damage remains one of the major bottlenecks to accurate structure solution in
protein crystallography. It can induce structural and chemical changes in protein crystals, and is …

The rational design of linear peptides that assemble controllably and predictably in water is
challenging. Short sequences must encode unique target structures and avoid alternative …

Ccr4-Not is a conserved protein complex that shortens the 3′ poly(A) tails of eukaryotic
mRNAs to regulate transcript stability and translation into proteins. RNA-binding proteins are …

Differential sensing attempts to mimic the mammalian senses of smell and taste to identify
analytes and complex mixtures. In place of hundreds of complex, membrane-bound G-protein …

De novo protein design is advancing rapidly. However, most designs are for single states.
Here we report a de novo designed peptide that forms multiple α-helical-bundle states that are …

Background Saliva is easily obtainable non-invasively and potentially suitable for detecting
both current and previous SARS-CoV-2 infection, but there is limited evidence on the utility of …

Radiation damage remains one of the major limitations to accurate structure determination
in protein crystallography (PX). Despite the use of cryo-cooling techniques, it is highly …

Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings
where active testing for virus is limited and remote sampling is optimal. We developed 12 …

Saliva is easily obtainable non-invasively and potentially suitable for detecting both current
and previous SARS-CoV-2 infection. We established 6 standardised enzyme linked …