INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural
networks and new quantification and signal correction strategies for the processing of data-…

Both the generation and the analysis of proteomics data are now widespread, and high-throughput
approaches are commonplace. Protocols continue to increase in complexity as …

The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …

Various mechanisms exist that enable bacteria to resist bacteriophage infection. Resistance
strategies include the abortive infection (Abi) systems, which promote cell death and limit …

A challenging task in the study of the secretory pathway is the identification and localization
of new proteins to increase our understanding of the functions of different organelles. …

Circadian rhythms are essential to health. Their disruption is associated with metabolic diseases
in experimental animals and man [1–3]. Local metabolic rhythms represent an output of …

iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …

The trafficking and function of cell surface proteins in eukaryotic cells may require association
with detergent-resistant sphingolipid- and sterol-rich membrane domains. The aim of this …

The dia-PASEF technology uses ion mobility separation to reduce signal interferences and
increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-…