User profiles for Kathryn S Lilley
![]() | kathryn lilleyProfessor of Cellular Dynamics Verified email at cam.ac.uk Cited by 31149 |
A subcellular map of the human proteome
INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …
molecular components of its smallest functional unit, the cell. Cells are internally organized …
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural
networks and new quantification and signal correction strategies for the processing of data-…
networks and new quantification and signal correction strategies for the processing of data-…
The minimum information about a proteomics experiment (MIAPE)
Both the generation and the analysis of proteomics data are now widespread, and high-throughput
approaches are commonplace. Protocols continue to increase in complexity as …
approaches are commonplace. Protocols continue to increase in complexity as …
[PDF][PDF] Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput …
The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair
…, IJ Foulds, DP Humphreys, KS Lilley… - Proceedings of the …, 2009 - National Acad Sciences
Various mechanisms exist that enable bacteria to resist bacteriophage infection. Resistance
strategies include the abortive infection (Abi) systems, which promote cell death and limit …
strategies include the abortive infection (Abi) systems, which promote cell death and limit …
Mapping the Arabidopsis organelle proteome
A challenging task in the study of the secretory pathway is the identification and localization
of new proteins to increase our understanding of the functions of different organelles. …
of new proteins to increase our understanding of the functions of different organelles. …
[HTML][HTML] Circadian orchestration of the hepatic proteome
Circadian rhythms are essential to health. Their disruption is associated with metabolic diseases
in experimental animals and man [1–3]. Local metabolic rhythms represent an output of …
in experimental animals and man [1–3]. Local metabolic rhythms represent an output of …
[HTML][HTML] Addressing accuracy and precision issues in iTRAQ quantitation
…, PG Sadowski, PD Charles, SV Hester, KS Lilley - Molecular & Cellular …, 2010 - ASBMB
iTRAQ (isobaric tags for relative or absolute quantitation) is a mass spectrometry technology
that allows quantitative comparison of protein abundance by measuring peak intensities of …
that allows quantitative comparison of protein abundance by measuring peak intensities of …
Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts
The trafficking and function of cell surface proteins in eukaryotic cells may require association
with detergent-resistant sphingolipid- and sterol-rich membrane domains. The aim of this …
with detergent-resistant sphingolipid- and sterol-rich membrane domains. The aim of this …
[HTML][HTML] dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts
…, J Decker, S Kaspar-Schoenefeld, KS Lilley… - Nature …, 2022 - nature.com
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and
increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-…
increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-…