Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

SNP-heritability is a fundamental quantity in the study of complex traits. Recent studies have
shown that existing methods to estimate genome-wide SNP-heritability can yield biases …

Although recent studies provide evidence for a common genetic basis between complex
traits and Mendelian disorders, a thorough quantification of their overlap in a phenotype-…

Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …

Background Large medical centers in urban areas, like Los Angeles, care for a diverse
patient population and offer the potential to study the interplay between genetic ancestry and …

The proportion of variation in complex traits that can be attributed to non-additive genetic
effects has been a topic of intense debate. The availability of biobank-scale datasets of …

While variance components analysis has emerged as a powerful tool in complex trait genetics,
existing methods for fitting variance components do not scale well to large-scale datasets …

MATTERS ARISING NATURE GENETICS other effect sizes or when the causal variant was
untyped and missing from the data, thus confirming that GWAS in admixed populations …

The number of variants that have a non-zero effect on a trait (ie. polygenicity) is a fundamental
parameter in the study of the genetic architecture of a complex trait. Although many …

Large medical centers located in urban areas such as Los Angeles care for a diverse patient
population and offer the potential to study the interplay between genomic ancestry and …