Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and
are essential for sustaining the blood and immune systems throughout life. Tight regulation …

How platelets are produced by megakaryocytes in vivo remains controversial despite more
than a century of investigation. Megakaryocytes readily produce proplatelet structures in vitro; …

Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC)
development. Here, we studied the involvement of RIG-I-like receptors (RLRs) in HSPC formation. …

In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells
of the embryonic yolk sac (YS), which are endowed with megakaryocytic potential, …

Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …

Clostridium difficile causes life-threatening diarrhea and is the leading cause of healthcare-associated
bacterial infections in the United States. TcdA and TcdB bacterial toxins are …

The thrombopoietic environment of the neonate is established during prenatal life; therefore,
a comprehensive understanding of platelet-forming cell development during …

Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations
of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early …

Hematopoietic stem cell transplantation (HSCT) is a treatment for many malignant, congenital,
and acquired hematologic diseases. Some outstanding challenges in the HSCT field …

Human myeloid malignancies represent a substantial disease burden to individuals, with
significant morbidity and death. The genetic underpinnings of disease formation and …