High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer
detection by enabling the identification of mutant cancer molecules in minimally invasive …

Cumulative evidence indicates that a significant proportion of cancer evolution may occur
before the development of histological abnormalities. While recent improvements in DNA …

Next-generation sequencing methods suffer from low recovery, uneven coverage, and false
mutations. DNA fragmentation by sonication is a major contributor to these problems …

Abstract Machine learning (ML) based interatomic potentials have transformed the field of
atomistic materials modelling. However, ML potentials depend critically on the quality and …

While mtDNA mutations might contribute to early ulcerative colitis tumorigenesis, they appear
to be selected against in cancer, suggesting that functional mitochondria might be required …

Objective Pap tests hold promise as a molecular diagnostic for serous ovarian cancer, but
previous studies reported limited sensitivity. Furthermore, the presence of somatic mutations in …

Gale and his co-workers (2) have reported that Gram-positive bacteria are able to assimilate
glutamic acid from the medium in which they are grown and to concentrate the free amino …

9566 Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a
recurrence rate of 40%. Early detection of recurrence can improve outcomes, and effective …

Current next-generation sequencing techniques suffer from inefficient target enrichment and
frequent errors. To address these issues, we have developed a targeted genome …

Managers have traditionally spent the majority of their time communicating in one form or
another (meetings, face-to-face discussions, memos, letters, e-mails, reports, etc.). Today, …