User profiles for Kathryn Tiedje
Kathryn E. TiedjeThe University of Melbourne, Bio21 Institute/Peter Doherty Institute Verified email at unimelb.edu.au Cited by 757 |
Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa
Existing theory on competition for hosts between pathogen strains has proposed that immune
selection can lead to the maintenance of strain structure consisting of discrete, weakly …
selection can lead to the maintenance of strain structure consisting of discrete, weakly …
[PDF][PDF] Community case management of childhood illnesses: policy and implementation in Countdown to 2015 countries
A Sousa, KE Tiedje, J Recht, I Bjelic… - Bulletin of the World …, 2012 - SciELO Public Health
OBJECTIVE: To explore the policies for, and implementation of, the community case
management (CCM) of childhood illnesses in the 68 countries that were prioritized by the "…
management (CCM) of childhood illnesses in the 68 countries that were prioritized by the "…
[HTML][HTML] Performance of SNP barcodes to determine genetic diversity and population structure of Plasmodium falciparum in Africa
Panels of informative biallelic single nucleotide polymorphisms (SNPs) have been proposed
to be an economical method to fast-track the population genetic analysis of Plasmodium …
to be an economical method to fast-track the population genetic analysis of Plasmodium …
[HTML][HTML] Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood …
Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-endemic
areas are at risk of infection throughout their lifetime. Here we seek to find a genomic …
areas are at risk of infection throughout their lifetime. Here we seek to find a genomic …
[HTML][HTML] Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
Pathogens compete for hosts through patterns of cross-protection conferred by immune
responses to antigens. In Plasmodium falciparum malaria, the var multigene family encoding for …
responses to antigens. In Plasmodium falciparum malaria, the var multigene family encoding for …
[HTML][HTML] Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum
In their competition for hosts, parasites with antigens that are novel to the host immune
system will be at a competitive advantage. The resulting frequency-dependent selection can …
system will be at a competitive advantage. The resulting frequency-dependent selection can …
[HTML][HTML] Seasonal variation in the epidemiology of asymptomatic Plasmodium falciparum infections across two catchment areas in Bongo District, Ghana
Understanding the epidemiology of asymptomatic Plasmodium falciparum infections is
critical for countries to move toward malaria elimination. Using different methods for parasite …
critical for countries to move toward malaria elimination. Using different methods for parasite …
[HTML][HTML] Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections
At a time when effective tools for monitoring malaria control and eradication efforts are crucial,
the increasing availability of molecular data motivates their application to epidemiology. …
the increasing availability of molecular data motivates their application to epidemiology. …
[HTML][HTML] Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana
High-malaria burden countries in sub-Saharan Africa are shifting from malaria control towards
elimination. Hence, there is need to gain a contemporary understanding of how indoor …
elimination. Hence, there is need to gain a contemporary understanding of how indoor …
[HTML][HTML] Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between …
Malaria remains a major public health problem in many countries. Unlike influenza and HIV,
where diversity in immunodominant surface antigens is understood geographically to inform …
where diversity in immunodominant surface antigens is understood geographically to inform …