User profiles for Kathryn Tiedje

Kathryn E. Tiedje

The University of Melbourne, Bio21 Institute/Peter Doherty Institute
Verified email at unimelb.edu.au
Cited by 757

Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa

KP Day, Y Artzy-Randrup, KE Tiedje… - Proceedings of the …, 2017 - National Acad Sciences
Existing theory on competition for hosts between pathogen strains has proposed that immune
selection can lead to the maintenance of strain structure consisting of discrete, weakly …

[PDF][PDF] Community case management of childhood illnesses: policy and implementation in Countdown to 2015 countries

A Sousa, KE Tiedje, J Recht, I Bjelic… - Bulletin of the World …, 2012 - SciELO Public Health
OBJECTIVE: To explore the policies for, and implementation of, the community case
management (CCM) of childhood illnesses in the 68 countries that were prioritized by the "…

[HTML][HTML] Performance of SNP barcodes to determine genetic diversity and population structure of Plasmodium falciparum in Africa

…, C Adobor, B Mensah, F Labbé, KE Tiedje… - Frontiers in …, 2023 - frontiersin.org
Panels of informative biallelic single nucleotide polymorphisms (SNPs) have been proposed
to be an economical method to fast-track the population genetic analysis of Plasmodium …

[HTML][HTML] Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood …

S Ruybal-Pesántez, KE Tiedje, S Pilosof… - International journal for …, 2022 - Elsevier
Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-endemic
areas are at risk of infection throughout their lifetime. Here we seek to find a genomic …

[HTML][HTML] Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

Q He, S Pilosof, KE Tiedje, S Ruybal-Pesántez… - Nature …, 2018 - nature.com
Pathogens compete for hosts through patterns of cross-protection conferred by immune
responses to antigens. In Plasmodium falciparum malaria, the var multigene family encoding for …

[HTML][HTML] Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum

S Pilosof, Q He, KE Tiedje, S Ruybal-Pesántez… - PLoS …, 2019 - journals.plos.org
In their competition for hosts, parasites with antigens that are novel to the host immune
system will be at a competitive advantage. The resulting frequency-dependent selection can …

[HTML][HTML] Seasonal variation in the epidemiology of asymptomatic Plasmodium falciparum infections across two catchment areas in Bongo District, Ghana

KE Tiedje, AR Oduro, G Agongo… - The American Journal …, 2017 - ncbi.nlm.nih.gov
Understanding the epidemiology of asymptomatic Plasmodium falciparum infections is
critical for countries to move toward malaria elimination. Using different methods for parasite …

[HTML][HTML] Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections

F Labbé, Q He, Q Zhan, KE Tiedje… - PLoS computational …, 2023 - journals.plos.org
At a time when effective tools for monitoring malaria control and eradication efforts are crucial,
the increasing availability of molecular data motivates their application to epidemiology. …

[HTML][HTML] Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana

KE Tiedje, AR Oduro, O Bangre… - PLOS global public …, 2022 - journals.plos.org
High-malaria burden countries in sub-Saharan Africa are shifting from malaria control towards
elimination. Hence, there is need to gain a contemporary understanding of how indoor …

[HTML][HTML] Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between …

G Tonkin-Hill, S Ruybal-Pesántez, KE Tiedje… - PLoS …, 2021 - journals.plos.org
Malaria remains a major public health problem in many countries. Unlike influenza and HIV,
where diversity in immunodominant surface antigens is understood geographically to inform …