User profiles for Kathy Ushakov
Kathy UshakovPostdoctoral fellow Verified email at broadinstitute.org Cited by 641 |
Genetics of hearing loss: syndromic
T Koffler, K Ushakov, KB Avraham - Otolaryngologic Clinics of …, 2015 - oto.theclinics.com
Hearing loss (HL) is the most prevalent sensory impairment in both childhood and adulthood.
1, 2 According to the last update of the World Health Organization (WHO), approximately …
1, 2 According to the last update of the World Health Organization (WHO), approximately …
[HTML][HTML] Reduced changes in protein compared to mRNA levels across non-proliferating tissues
K Perl, K Ushakov, Y Pozniak, O Yizhar-Barnea… - BMC genomics, 2017 - Springer
Background The quantitative relations between RNA and protein are fundamental to
biology and are still not fully understood. Across taxa, it was demonstrated that the protein-to-mRNA …
biology and are still not fully understood. Across taxa, it was demonstrated that the protein-to-mRNA …
[HTML][HTML] Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways
A Rudnicki, O Isakov, K Ushakov, S Shivatzki, I Weiss… - BMC genomics, 2014 - Springer
Background The mammalian inner ear contains sensory organs, the organ of Corti in the
cochlea and cristae and maculae in the vestibule, with each comprised of patterned sensory …
cochlea and cristae and maculae in the vestibule, with each comprised of patterned sensory …
miR-96 is required for normal development of the auditory hindbrain
…, P Fieth, C Krohs, K Ushakov… - Human molecular …, 2018 - academic.oup.com
The peripheral deafness gene Mir96 is expressed in both the cochlea and central auditory
circuits. To investigate whether it plays a role in the auditory system beyond the cochlea, we …
circuits. To investigate whether it plays a role in the auditory system beyond the cochlea, we …
[HTML][HTML] MicroRNAs in sensorineural diseases of the ear
K Ushakov, A Rudnicki, KB Avraham - Frontiers in molecular …, 2013 - frontiersin.org
Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression
in almost every multicellular organism. Only discovered in the last decade, miRNAs are …
in almost every multicellular organism. Only discovered in the last decade, miRNAs are …
[HTML][HTML] Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells
H Ruhanen, K Ushakov, T Yasukawa - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
Recent evidence suggests that coupled leading and lagging strand DNA synthesis operates
in mammalian mitochondrial DNA (mtDNA) replication, but the factors involved in lagging …
in mammalian mitochondrial DNA (mtDNA) replication, but the factors involved in lagging …
[HTML][HTML] DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory sensory epithelium
…, K Kishore, C Andrus, T Koffler-Brill, K Ushakov… - Scientific reports, 2018 - nature.com
The inner ear is a complex structure responsible for hearing and balance, and organ pathology
is associated with deafness and balance disorders. To evaluate the role of epigenomic …
is associated with deafness and balance disorders. To evaluate the role of epigenomic …
The GPSM2/LGN GoLoco motifs are essential for hearing
Y Bhonker, A Abu-Rayyan, K Ushakov… - Mammalian …, 2016 - Springer
The planar cell polarity (PCP) pathway is responsible for polarizing and orienting cochlear
hair cells during development through movement of a primary cilium, the kinocilium. GPSM2/…
hair cells during development through movement of a primary cilium, the kinocilium. GPSM2/…
[HTML][HTML] Time-dependent gene expression analysis of the developing superior olivary complex
…, N Hartmann, M Clément-Ziza, K Ushakov… - Journal of Biological …, 2013 - ASBMB
The superior olivary complex (SOC) is an essential auditory brainstem relay involved in sound
localization. To identify the genetic program underlying its maturation, we profiled the rat …
localization. To identify the genetic program underlying its maturation, we profiled the rat …
[HTML][HTML] Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems
Mammalian genomes encode multiple layers of regulation, including a class of RNA molecules
known as long non-coding RNAs (lncRNAs). These are >200 nucleotides in length and …
known as long non-coding RNAs (lncRNAs). These are >200 nucleotides in length and …