Neutrophil recruitment is an important early step in controlling tissue infections or injury.
Here, we report that this influx depends on both tissue-resident mast cells and macrophages. …

A successful immune response depends on the capacity of immune cells to travel from one
location in the body to another–these cells are rapid migrators, travelling at speeds of μm/…

Neutrophils are the first immune cells to migrate into infected tissue sites. Therefore an
important step in the initiation of an immune response is the synthesis of the neutrophil-recruiting …

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells …

Emergency mobilization of neutrophil granulocytes (neutrophils) from the bone marrow (BM)
is a key event of early cellular immunity. The hematopoietic cytokine granulocyte-colony …

Background Chemokines play a critical role in orchestrating the distribution and trafficking
of neutrophils in homeostasis and disease. Results The CXCR 4/ CXCL 12 chemokine axis …

Neutrophils and T cells play an important role in host protection against pulmonary infection
caused by Streptococcus pneumoniae. However, the role of the integrins in recruitment of …

Neutrophils are the most abundant circulating leukocyte within the blood stream and for
many years the dogma has been that these cells migrate rapidly into tissues in response to …

Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally
available and potent CXCR4 antagonists were pursued. One such proposition was …

The S100A8/A9 heterodimer is abundantly expressed by myeloid cells, especially neutrophils,
but its mechanism of action is only partially determined. In this study we investigated …