Disruption of the cyclin-dependent kinase–inhibitory domain of p27 enhances growth of mice.
Growth is attributed to an increase in cell number, due to increased cell proliferation, most …

Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation
and surgery to optimize outcomes for individual patients. No accurate model of RC exists to …

Purpose To establish the prognostic value of biopsy of the central and marginal ablation
zones for time to local tumor progression (LTP) after radiofrequency (RF) ablation of colorectal …

The DNA damage response (DDR) is activated by oncogenic stress, but the mechanisms by
which this occurs, and the particular DDR functions that constitute barriers to tumorigenesis, …

Background This study aimed to evaluate whether rapid fluorescent tissue examination
immediately after colorectal cancer liver metastasis (CLM) ablation correlates with standard …

Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and
relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM + …

Tunneling nanotubes (TnTs) are long, non-adherent, actin-based cellular extensions that
act as conduits for transport of cellular cargo between connected cells. The mechanisms of …

Purpose: Both heat shock protein 90 (Hsp90) and checkpoint kinase 1 (Chk1) have emerged
as novel therapeutic targets. We conducted a phase I study of irinotecan and the Hsp90 …

Exosomes, small membrane vesicles (30-100 nm) of endocytic origin secreted by most cell
types, contain functional biomolecules, which can be horizontally transferred to recipient cells …

TGF-β and BMP receptor kinases activate Smad transcription factors by C-terminal
phosphorylation. We have identified a subsequent agonist-induced phosphorylation that plays a …