Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

KC Bittner, C Grienberger, SP Vaidya, AD Milstein… - Nature …, 2015 - nature.com
Feature-selective firing allows networks to produce representations of the external and
internal environments. Despite its importance, the mechanisms generating neuronal feature …

Behavioral time scale synaptic plasticity underlies CA1 place fields

KC Bittner, AD Milstein, C Grienberger, S Romani… - Science, 2017 - science.org
Learning is primarily mediated by activity-dependent modifications of synaptic strength within
neuronal circuits. We discovered that place fields in hippocampal area CA1 are produced …

Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells

C Grienberger, AD Milstein, KC Bittner, S Romani… - Nature …, 2017 - nature.com
Place cells in the CA1 region of the hippocampus express location-specific firing despite
receiving a steady barrage of heterogeneously tuned excitatory inputs that should compromise …

[PDF][PDF] Axonal filtering allows reliable output during dendritic plateau-driven complex spiking in CA1 neurons

PF Apostolides, AD Milstein, C Grienberger, KC Bittner… - Neuron, 2016 - cell.com
In CA1 pyramidal neurons, correlated inputs trigger dendritic plateau potentials that drive
neuronal plasticity and firing rate modulation. Given the strong electrotonic coupling between …

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

AD Milstein, Y Li, KC Bittner, C Grienberger, I Soltesz… - Elife, 2021 - elifesciences.org
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic
plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic calcium …

[HTML][HTML] " Hyperglutamatergic cortico-striato-thalamo-cortical circuit" breaker drugs alleviate tics in a transgenic circuit model of Tourette׳ s syndrome

EJ Nordstrom, KC Bittner, MJ McGrath, CR Parks III… - Brain research, 2015 - Elsevier
The brain circuits underlying tics in Tourette׳s syndrome (TS) are unknown but thought to
involve cortico/amygdalo-striato-thalamo-cortical (CSTC) loop hyperactivity. We previously …

[HTML][HTML] Ion channel gradients in the apical tuft region of CA1 pyramidal neurons

KC Bittner, BK Andrasfalvy, JC Magee - 2012 - journals.plos.org
Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally
important for synaptic integration and plasticity. In the hippocampal region CA1, somato-…

Mild traumatic brain injury induced by primary blast overpressure produces dynamic regional changes in [18F] FDG uptake

…, CM Wilson, AH Fu, LB Tucker, Y Kim, KC Bittner… - Brain research, 2019 - Elsevier
Abstract Changes in 18 F-fluorodeoxyglucose ([ 18 F]FDG) measured by positron emission
tomography (PET) can be used for the noninvasive detection of metabolic dysfunction …

Discordance between documented criteria and documented diagnosis of traumatic brain injury in the emergency department

MR Cota, AD Moses, NR Jikaria, KC Bittner… - Journal of …, 2019 - liebertpub.com
Accurate diagnosis of traumatic brain injury (TBI) is critical to ensure that patients receive
appropriate follow-up care, avoid risk of subsequent injury, and are aware of possible long-…

[PDF][PDF] Current perspectives on the use of fetal fibronectin testing in preterm labor diagnosis and management

MS Ruma, KC Bittner, CB Soh - Am. J. Manag. Care, 2017 - researchgate.net
CURRENT PERSPECTIVES ON THE USE OF fFN TESTING overstated. This paper examines
several clinical guidelines, algorithms, and additional evidence from published studies …