User profiles for Katie E. Lotterhos

Katie E. Lotterhos

Northeastern University
Verified email at neu.edu
Cited by 4353

Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016 - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high-quality …

Evaluation of demographic history and neutral parameterization on the performance of FST outlier tests

KE Lotterhos, MC Whitlock - Molecular ecology, 2014 - Wiley Online Library
F ST outlier tests are a potentially powerful way to detect genetic loci under spatially divergent
selection. Unfortunately, the extent to which these tests are robust to nonequilibrium …

The relative power of genome scans to detect local adaptation depends on sampling design and statistical method

KE Lotterhos, MC Whitlock - Molecular ecology, 2015 - Wiley Online Library
Although genome scans have become a popular approach towards understanding the
genetic basis of local adaptation, the field still does not have a firm grasp on how sampling …

Reliable Detection of Loci Responsible for Local Adaptation: Inference of a Null Model through Trimming the Distribution of FST

MC Whitlock, KE Lotterhos - The American Naturalist, 2015 - journals.uchicago.edu
Loci responsible for local adaptation are likely to have more genetic differentiation among
populations than neutral loci. However, neutral loci can vary widely in their amount of genetic …

Breaking RAD: An evaluation of the utility of restriction site‐associated DNA sequencing for genome scans of adaptation

DB Lowry, S Hoban, JL Kelley, KE Lotterhos, LK Reed… - 2017 - Wiley Online Library
Understanding how and why populations evolve is of fundamental importance to molecular
ecology. Restriction site‐associated DNA sequencing ( RAD seq), a popular reduced …

The paradox of adaptive trait clines with nonclinal patterns in the underlying genes

KE Lotterhos - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Multivariate climate change presents an urgent need to understand how species adapt to
complex environments. Population genetic theory predicts that loci under selection will form …

Convergent local adaptation to climate in distantly related conifers

S Yeaman, KA Hodgins, KE Lotterhos, H Suren… - Science, 2016 - science.org
When confronted with an adaptive challenge, such as extreme temperature, closely related
species frequently evolve similar phenotypes using the same genes. Although such repeated …

Inversion invasions: when the genetic basis of local adaptation is concentrated within inversions in the face of gene flow

…, BC Haller, KE Lotterhos - … Transactions of the …, 2022 - royalsocietypublishing.org
Across many species where inversions have been implicated in local adaptation, genomes
often evolve to contain multiple, large inversions that arise early in divergence. Why this …

Elevated pCO2 increases sperm limitation and risk of polyspermy in the red sea urchin Strongylocentrotus franciscanus

KE Reuter, KE Lotterhos, RN Crim… - Global Change …, 2011 - Wiley Online Library
Anthropogenic carbon dioxide (CO 2 ) emissions and the resultant acidification of surface
ocean waters are predicted to have far‐reaching consequences for biological processes in the …

[HTML][HTML] Novel and disappearing climates in the global surface ocean from 1800 to 2100

KE Lotterhos, ÁJ Láruson, LQ Jiang - Scientific Reports, 2021 - nature.com
Marine ecosystems are experiencing unprecedented warming and acidification caused by
anthropogenic carbon dioxide. For the global sea surface, we quantified the degree that …