Background Effective targeted therapy for sepsis requires an understanding of the
heterogeneity in the individual host response to infection. We investigated this heterogeneity by …

Background Host responses during sepsis are highly heterogeneous, which hampers the
identification of patients at high risk of mortality and their selection for targeted therapies. In this …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Sepsis arises from diverse and incompletely understood dysregulated host response processes
following infection that leads to life-threatening organ dysfunction. Here we showed that …

Rationale: There remains uncertainty about the role of corticosteroids in sepsis with clear
beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical
severity scores and available assays such as blood lactate reflect global illness severity …

Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of
efficacy on early target selection 1 . Drug targets with genetic support are more likely to be …

Rationale: Heterogeneity in the septic response has hindered efforts to understand
pathophysiology and develop targeted therapies. Source of infection, with different causative …

Although alterations in myeloid cells have been observed in COVID-19, the specific underlying
mechanisms are not completely understood. Here, we examine the function of classical …

Background Biological interpretation of genomic summary data such as those resulting from
genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) …