The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear,
however, how Hippo signalling provides the cellular building blocks required for rapid growth…

Methods| We performed a retrospective cohort study (2013-2016) of patients with metastatic
lung cancer treated with PD-1/PD-L1 (programmed cell death 1/programmed cell death 1 …

The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation.
While many modulators of Hippo activity have been identified, little is known about the Yap …

Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated
into a class of selenocysteine-containing proteins (selenoproteins). Selenoprotein H (…

The liver and pancreas arise from common endodermal progenitors. How these distinct cell
fates are specified is poorly understood. Here we describe prostaglandin E 2 (PGE 2 ) as a …

Meningiomas account for approximately one-third of primary central nervous system tumors
with a subset that are aggressive and carry significant morbidity and mortality. Treatment of …

The rapidly growing array of therapeutic options in cancer requires informative biomarkers
to guide the rational selection and precision application of appropriate therapies. Circulating …

Liver and pancreatic cancers are amongst the leading causes of cancer death. In recent
years, genetic and chemical approaches in zebrafish have elucidated cellular and molecular …

Background Metastatic esophagogastric cancers (EGCs) have a poor prognosis with an
approximately 5% 5‐year survival. Additional treatment approaches are needed. c‐MET gene‐…

The Hippo pathway has recently emerged as a key regulator of organ size and tumor formation;
however, the exact molecular mechanisms leading to enlarged organ size are not well …