Self-specific CD8 + T cells can escape clonal deletion, but the properties and capabilities of
such cells in a physiological setting are unclear. We characterized polyclonal CD8 + T cells …

Self-specific CD8+ T cells often escape clonal deletion, but the properties and capabilities of
such cells in a physiological setting are unclear. We characterized polyclonal CD8 + T cells …

To characterize the proteomic signature of chronological age, 1,301 proteins were measured
in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a population of …

Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic lupus
erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute to …

Background A pharmacologic intervention that modulates JAK/STAT signaling pathways
represents a novel approach for the treatment of Systemic Lupus Erythematosus (SLE). In …

The report from the Intergovernmental Panel on Climate Change issued in October of 2018
paints a dire picture. Responding to the transnational Paris Agreement (made just two years …

The year 2021 was a remarkable one on many levels for M&A and the transactional market
more broadly. Building on the strong market that began in the middle of 2020 following a …

Tolerant self-antigen–specific CD8 T cells fail to proliferate in response to antigen, thereby
preventing autoimmune disease. By using an in vivo mouse model, we show that tolerant T …

Bodies of Knowledge challenges homogenizing (mis) understandings of knowledge
construction and provides a complex discussion of what happens when we do not attend to …

Background Interest in single-cell transcriptomic analysis is growing rapidly, especially for
profiling rare or heterogeneous populations of cells. In almost all reported works investigators …