Apoptosis is a highly regulated form of programmed cell death, essential to the development
and homeostasis of multicellular organisms. Cytochrome c is a central figure in the …

Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the
postischemic brain upon neuroprotective insulin treatment, but how such posttranslational …

Cytochrome c (Cc) is a protein that functions as an electron carrier in the mitochondrial
respiratory chain. However, Cc has moonlighting roles outside mitochondria driving the transition …

Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control
oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as …

Chromatin is pivotal for regulation of the DNA damage process insofar as it influences
access to DNA and serves as a DNA repair docking site. Recent works identify histone …

Since the first description of apoptosis four decades ago, great efforts have been made to
elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. …

Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative
DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, …

Programmed cell death is an event displayed by many different organisms along the
evolutionary scale. In plants, programmed cell death is necessary for development and the …

The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered
unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus …

Dear Editor, In mammals, the intrinsic pathway of apoptosis, or programmed cell death (PCD),
mainly involves activation of the apoptosome-dependent caspase cascade upon binding …