[HTML][HTML] Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
…, AC Walls, MA Tortorici, S Bianchi, S Jaconi, K Culap… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
[HTML][HTML] Sensitivity of SARS-CoV-2 B. 1.1. 7 to mRNA vaccine-elicited antibodies
…, S Bianchi, MA Tortorici, J Bowen, K Culap… - Nature, 2021 - nature.com
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded
in some areas by the higher transmission potential of the B.1.1.7 variant 1 , which has …
in some areas by the higher transmission potential of the B.1.1.7 variant 1 , which has …
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
…, R Spreafico, J Dillen, C Ng, N Sprugasci, K Culap… - Science, 2020 - science.org
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
SARS-CoV-2 immune evasion by the B. 1.427/B. 1.429 variant of concern
…, C Saliba, KR Sprouse, M Agostini, D Pinto, K Culap… - Science, 2021 - science.org
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
[HTML][HTML] SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
…, G Lombardo, M Agostini, N Sprugasci, K Culap… - Nature, 2021 - nature.com
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape 1 , 2 – 3 , have
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …
[HTML][HTML] Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
…, H Kaiser, S Islam, S Jaconi, N Sprugasci, K Culap… - Science, 2021 - science.org
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
[HTML][HTML] Broad sarbecovirus neutralization by a human monoclonal antibody
The recent emergence of SARS-CoV-2 variants of concern 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
[PDF][PDF] Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
…, J Bassi, A O'Toole, D Pinto, RM Colquhoun, K Culap… - Cell, 2021 - cell.com
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-…
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-…
Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70
SARS-CoV-2 amino acid replacements in the receptor binding domain (RBD) occur
relatively frequently and some have a consequence for immune recognition. Here we report …
relatively frequently and some have a consequence for immune recognition. Here we report …