During embryonic and postnatal development, Wnt/β-catenin signaling is involved in several
stages of hair morphogenesis from placode formation to hair shaft differentiation. Using a …

In hair follicle development, a placode-derived signal is believed to induce formation of the
dermal condensation, an essential component of ectodermal organs. However, the identity of …

Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from
solid tumours together with their native microenvironment. They offer a low throughput but …

10.7554/eLife.36468.001 Mesenchymal condensation is a critical step in organogenesis,
yet the underlying molecular and cellular mechanisms remain poorly understood. The hair …

Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine.
We studied how the cell of origin contributes to phenotypic heterogeneity following …

Mammary glands and hair follicles develop as ectodermal organs sharing common features
during embryonic morphogenesis. The molecular signals controlling the initiation and …

Two-dimensional (2D) culture of cancer cells in vitro does not recapitulate the three-dimensional
(3D) architecture, heterogeneity and complexity of human tumors. More representative …

A key question in precision medicine is how functional heterogeneity in solid tumours informs
therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling …

These findings identify the cell-surface serine protease hepsin as a potential therapeutic
target for its role in oncogenic Ras-mediated deregulation of epithelial cell–cell and cell–matrix …

Organotypic primary tissue explant cultures, which include precision-cut slices, represent the
three-dimensional (3-D) tissue architecture as well as the multicellular interactions of native …