Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial

…, H Tinkanen, R Bloigu, K Puukka… - The Journal of …, 2012 - academic.oup.com
Background: The role of metformin in the treatment of infertility in women with polycystic ovary
syndrome (PCOS) is still controversial. Objective and Outcomes: We investigated whether …

Weight gain and dyslipidemia in early adulthood associate with polycystic ovary syndrome: prospective cohort study

MME Ollila, T Piltonen, K Puukka… - The Journal of …, 2016 - academic.oup.com
Context: Obesity affects the majority of women with polycystic ovary syndrome (PCOS), but
previous studies are inconsistent about the prevalence of obesity and the importance of …

[HTML][HTML] Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index

PI Alatalo, HM Koivisto, JP Hietala, KS Puukka… - The American journal of …, 2008 - Elsevier
Background: Although both ethanol consumption and overweight alter the activities of
hepatic enzymes in circulation, the differentiation of an alcohol or nonalcohol basis for such …

[HTML][HTML] Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

…, J Kettunen, J Jokelainen, J Auvinen, K Puukka… - Diabetologia, 2019 - Springer
Aims/hypothesis Metabolomics technologies have identified numerous blood biomarkers for
type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed …

Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

…, M Tiainen, T Tynkkynen, K Puukka… - International journal …, 2015 - academic.oup.com
Background: The causal role of circulating sex hormone-binding globulin (SHBG) for type 2
diabetes is controversial. Information on the relations between SHBG and new biomarkers of …

Androgen profile through life in women with polycystic ovary syndrome: a Nordic multicenter collaboration study

…, A Ruokonen, K Puukka… - The Journal of …, 2015 - academic.oup.com
Katri Puukka , Katri Puukka … Piltonen, Johanna Puurunen, Eszter Vanky, Inger
Sundström-Poromaa, Elisabet Stener-Victorin, Aimo Ruokonen, Katri Puukka, Juha S. Tapanainen, …

[HTML][HTML] Normo-and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

P Pinola, K Puukka, TT Piltonen, J Puurunen, E Vanky… - Fertility and sterility, 2017 - Elsevier
Objective To compare the metabolic profiles of normo- and hyperandrogenic women with
polycystic ovary syndrome (PCOS) with those of control women at different ages during …

Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up

…, J Auvinen, A Ruokonen, K Puukka… - The Journal of …, 2017 - academic.oup.com
Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological
distress, obesity and hyperandrogenism being suggested as key promoters. Objectives: To …

Statin therapy worsens insulin sensitivity in women with polycystic ovary syndrome (PCOS): a prospective, randomized, double-blind, placebo-controlled study

J Puurunen, T Piltonen, K Puukka… - The Journal of …, 2013 - academic.oup.com
Context: Statins have been shown to improve hyperandrogenism in women with polycystic
ovary syndrome (PCOS). However, their use has also been associated with impairment of …

Biomarkers of liver status in heavy drinkers, moderate drinkers and abstainers

P Alatalo, H Koivisto, K Puukka, J Hietala… - Alcohol & …, 2009 - academic.oup.com
Aims: Although a wide variety of biomarkers reflecting liver status are known to be influenced
by excessive ethanol consumption, the dose–response relationships between ethanol …