Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the
hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here
we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), …

Muscle regeneration is sustained by infiltrating macrophages and the consequent activation
of satellite cells 1 , 2 , 3 – 4 . Macrophages and satellite cells communicate in different ways …

Exercise is a powerful driver of physiological angiogenesis during adulthood, but the
mechanisms of exercise-induced vascular expansion are poorly understood. We explored …

Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel
normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor …

Strategies targeting pathological angiogenesis have focused primarily on blocking vascular
endothelial growth factor (VEGF), but resistance and insufficient efficacy limit their success, …

Filopodia, “the fingers that do the walking,” have been identified on endothelial cells at the
tip of sprouting vessels for half a century, but the key role of the tip cell in vessel branching …

Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it
is unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced …