We report the engineering of mScarlet, a truly monomeric red fluorescent protein with record
brightness, quantum yield (70%) and fluorescence lifetime (3.9 ns). We developed mScarlet …

In mammalian cells, the MYC oncoprotein binds to thousands of promoters 1 , 2 , 3 , 4 .
During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the …

The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs,
zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. …

In several developmental lineages, an increase in MYC expression drives the transition from
quiescent stem cells to transit-amplifying cells. We show that MYC activates a stereotypic …

A hallmark of MYC-transformed cells is their aberrant response to antimitogenic signals. Key
examples include the inability of MYC-transformed cells to arrest proliferation in response to …

MYC is one of the most frequently overexpressed oncogenes in human cancer, and even
modestly deregulated MYC can initiate ectopic proliferation in many postmitotic cell types in …

Since the original outbreak of the SARS-CoV-2 virus, several rapidly spreading SARS-CoV-2
variants of concern (VOC) have emerged. Here, we show that a single dose of Ad26.COV2.…

Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli, and this
protects long‐lived organisms from cancer development. How cells discriminate physiological …

Apoptosis caused by deregulated MYC expression is a prototype example of intrinsic tumor
suppression. However, it is still unclear how supraphysiological MYC expression levels …

In the past forty years, the WNT/CTNNB1 signaling pathway has emerged as a key player in
mammary gland development and homeostasis. While also evidently involved in breast …