Interleukin‐2 (IL‐2) has multiple, sometimes opposing, functions during an inflammatory
response. It is a potent inducer of T‐cell proliferation and T‐helper 1 (Th1) and Th2 effector T‐…

IL-2 controls the survival of regulatory T cells (Tregs), but it is unclear whether IL-2 also
directly affects Treg suppressive capacity in vivo. We have found that eliminating Bim-dependent …

Until recently, little was known about the importance of CD8+ T effectors in promoting and
preventing autoimmune disease development. CD8+ T cells can oppose or promote …

Increased resistance to apoptosis promotes lymphomagenesis with aberrant expression of
cell survival proteins such as BCL-2 and c-MYC occurring in distinct lymphoma subtypes. …

The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially
from AIDS patients. To determine whether aberrant expression promotes B cell transformation, …

The immune system has been implicated as an important modulator of tissue regeneration.
However, the mechanisms driving injury-induced immune response and tissue repair remain …

CD8 T cells can play both a protective and pathogenic role in inflammation and autoimmune
development. Recent studies have highlighted the ability of CD8 T cells to function as T …

CD8 T cells are infrequently considered part of germinal center reactions. Yet, a distinct
CXCR5+ CD8 T cell subset identified within the B cell follicle and germinal center in situations of …

Activation of the TCL1 oncogene has been implicated in T cell leukemias/lymphomas and
recently was associated with AIDS diffuse large B cell lymphomas (AIDS-DLBCL). Also, in …

Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is
implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by …