[HTML][HTML] Modulation of pathological pain by epidermal growth factor receptor

JP Borges, K Mekhail, GD Fairn… - Frontiers in …, 2021 - frontiersin.org
Chronic pain has been widely recognized as a major public health problem that impacts
multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to …

[HTML][HTML] Examining the underappreciated role of S-acylated proteins as critical regulators of phagocytosis and phagosome maturation in macrophages

CL Dixon, K Mekhail, GD Fairn - Frontiers in Immunology, 2021 - frontiersin.org
Phagocytosis is a receptor-mediated process used by cells to engulf a wide variety of
particulates, including microorganisms and apoptotic cells. Many of the proteins involved in this …

[PDF][PDF] Fatty acid synthase inhibition prevents palmitoylation of SARS-CoV2 spike protein and improves survival of mice infected with murine hepatitis virus

M Lee, M Sugiyama, K Mekhail, E Latreille… - BioRxiv, 2020 - researchgate.net
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the causative agent of
COVID19 that has infected> 76M people and caused> 1.68 M deaths. The SARS-CoV2 Spike …

[HTML][HTML] FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

K Mekhail, M Lee, M Sugiyama, A Astori… - Journal of Lipid …, 2022 - ASBMB
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically …

Investigating the Role of Fatty-Acid Synthesis and S-Palmitoylation on Coronavirus Infection

K Mekhail - 2022 - search.proquest.com
… Unless otherwise indicated, experiments were completed by Katrina Mekhail. Many have
contributed to this work as briefly described here. Each person is credited in figure legends for …

Palmitoylation of SARS‐CoV‐2 Spike Protein is prevented by Fatty Acid Synthase Inhibitors

K Mekhail - The FASEB Journal, 2021 - Wiley Online Library
The COVID‐19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2),
has resulted in a significant loss of human life due in part to the paucity of …

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses (preprint)

K Mekhail, M Lee, M Sugiyama, A Astori, J St-Germain… - 2020 - pesquisa.bvsalud.org
The Spike protein of SARS-CoV2 and other coronaviruses mediate host cell entry and are S-acylated
on multiple phylogenetically conserved cysteine residues. Multiple protein …

Fatty Acid Synthase inhibition prevents palmitoylation of SARS-CoV2 SpikeProtein and improves survival of mice infected with murine hepatitis virus.

K Mekhail, M Lee, M Sugiyama, A Astori, J St-Germain… - 2020 - pesquisa.bvsalud.org
The Spike protein of SARS-CoV2 and other coronaviruses mediate host cell entry and are S-acylated
on multiple phylogenetically conserved cysteine residues. Multiple protein …

Dynamic ER-PM contact sites and their impact on lipid homeostasis of phosphotyrosine signaling

M Lee - 2022 - search.proquest.com
Membrane contact sites (MCS) are specialized cellular structures where two opposed
membranes of intracellular organelles form a close gap (~ 20nm). These regions serve as …

[HTML][HTML] Holistic treatment response: an international expert panel definition and criteria for a new paradigm in the assessment of clinical outcomes of spinal cord …

RM Levy, N Mekhail, A Abd-Elsayed, D Abejón… - … : Technology at the …, 2023 - Elsevier
Background Treatment response to spinal cord stimulation (SCS) is focused on the magnitude
of effects on pain intensity. However, chronic pain is a multidimensional condition that …