[HTML][HTML] Glucagon receptor signaling and glucagon resistance
L Janah, S Kjeldsen, KD Galsgaard… - International journal of …, 2019 - mdpi.com
Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion that …
measurement of glucagon has been essential for uncovering its pathological hypersecretion that …
[HTML][HTML] Glucagon receptor signaling and lipid metabolism
Glucagon is secreted from the pancreatic alpha cells upon hypoglycemia and stimulates
hepatic glucose production. Type 2 diabetes is associated with dysregulated glucagon secretion…
hepatic glucose production. Type 2 diabetes is associated with dysregulated glucagon secretion…
The Liver–α-Cell Axis and Type 2 Diabetes
…, J Pedersen, KD Galsgaard… - Endocrine …, 2019 - academic.oup.com
Both type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD) strongly associate
with increasing body mass index, and together these metabolic diseases affect millions of …
with increasing body mass index, and together these metabolic diseases affect millions of …
[HTML][HTML] Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
M Winther-Sørensen, KD Galsgaard, A Santos… - Molecular …, 2020 - Elsevier
Objective Glucagon is well known to regulate blood glucose but may be equally important
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon-…
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon-…
Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis
KD Galsgaard, M Winther-Sørensen… - American Journal …, 2018 - journals.physiology.org
Glucagon secreted from the pancreatic alpha-cells is essential for regulation of blood glucose
levels. However, glucagon may play an equally important role in the regulation of amino …
levels. However, glucagon may play an equally important role in the regulation of amino …
The liver–α-cell axis in health and in disease
MM Richter, KD Galsgaard, E Elmelund, FK Knop… - Diabetes, 2022 - Am Diabetes Assoc
Glucagon and insulin are the main regulators of blood glucose. While the actions of insulin
are extensively mapped, less is known about glucagon. Besides glucagon’s role in glucose …
are extensively mapped, less is known about glucagon. Besides glucagon’s role in glucose …
[HTML][HTML] Evidence of a liver–alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino …
…, Y Mahendran, AE Jonsson, KD Galsgaard… - Diabetologia, 2018 - Springer
Aims/hypothesis The secretion of glucagon is controlled by blood glucose and inappropriate
secretion of glucagon contributes to hyperglycaemia in diabetes. Besides its role in glucose …
secretion of glucagon contributes to hyperglycaemia in diabetes. Besides its role in glucose …
Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes
…, F Wibrand, AM Lund, KD Galsgaard… - American Journal …, 2018 - journals.physiology.org
Patients with type 2 diabetes (T2D) and patients with nonalcoholic fatty liver disease (NAFLD)
frequently exhibit elevated plasma concentrations of glucagon (hyperglucagonemia). …
frequently exhibit elevated plasma concentrations of glucagon (hyperglucagonemia). …
Alanine, arginine, cysteine, and proline, but not glutamine, are substrates for, and acute mediators of, the liver-α-cell axis in female mice
KD Galsgaard, SL Jepsen… - American Journal …, 2020 - journals.physiology.org
The aim of this study was to identify the amino acids that stimulate glucagon secretion in
mice and whose metabolism depends on glucagon receptor signaling. Pancreata of female …
mice and whose metabolism depends on glucagon receptor signaling. Pancreata of female …
[HTML][HTML] Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
…, D Hornburg, J Pedersen, EP Jensen, KD Galsgaard… - Diabetologia, 2017 - Springer
Aims/hypothesis In humans, glucagon-like peptide-1 (GLP-1) is rapidly degraded by
dipeptidyl peptidase-4 to a relatively stable metabolite, GLP-1(9–36)NH 2 , which allows …
dipeptidyl peptidase-4 to a relatively stable metabolite, GLP-1(9–36)NH 2 , which allows …