User profiles for Kaushik Ragunathan
 | Kaushik RagunathanBiology Verified email at brandeis.edu Cited by 1488 |
Epigenetic inheritance uncoupled from sequence-specific recruitment
K Ragunathan, G Jih, D Moazed - Science, 2015 - science.org
INTRODUCTION Changes in histone posttranslational modifications are associated with
epigenetic states that define distinct patterns of gene expression. Whereas sequence-specific …
epigenetic states that define distinct patterns of gene expression. Whereas sequence-specific …
Protein-guided RNA dynamics during early ribosome assembly
The assembly of 30S ribosomes requires the precise addition of 20 proteins to the 16S
ribosomal RNA. How early binding proteins change the ribosomal RNA structure so that later …
ribosomal RNA. How early binding proteins change the ribosomal RNA structure so that later …
Probing cellular protein complexes using single-molecule pull-down
Proteins perform most cellular functions in macromolecular complexes. The same protein
often participates in different complexes to exhibit diverse functionality. Current ensemble …
often participates in different complexes to exhibit diverse functionality. Current ensemble …
An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase
H3K9 methylation (H3K9me) specifies the establishment and maintenance of
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
[HTML][HTML] Single-molecule four-color FRET
… Jinwoo Lee, † Sanghwa Lee, † Kaushik Ragunathan, Dr. Chirlmin Joo, Prof. Dr. … Our
systematic two-color FRET analysis showed that the zero delay corresponds to strand …
systematic two-color FRET analysis showed that the zero delay corresponds to strand …
RecA filament sliding on DNA facilitates homology search
10.7554/eLife.00067.001 During homologous recombination, RecA forms a helical filament
on a single stranded (ss) DNA that searches for a homologous double stranded (ds) DNA …
on a single stranded (ss) DNA that searches for a homologous double stranded (ds) DNA …
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1
…, AP Boyle, PJ O'Brien, K Ragunathan… - Nature structural & …, 2023 - nature.com
Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. …
achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. …
[PDF][PDF] Real-time observation of strand exchange reaction with high spatiotemporal resolution
RecA binds to single-stranded (ss) DNA to form a helical filament that catalyzes strand
exchange with a homologous double-stranded (ds) DNA. The study of strand exchange in …
exchange with a homologous double-stranded (ds) DNA. The study of strand exchange in …
ATP-independent diffusion of double-stranded RNA binding proteins
HR Koh, MA Kidwell, K Ragunathan… - Proceedings of the …, 2013 - National Acad Sciences
The proteins harboring double-stranded RNA binding domains (dsRBDs) play diverse
functional roles such as RNA localization, splicing, editing, export, and translation, yet …
functional roles such as RNA localization, splicing, editing, export, and translation, yet …
[HTML][HTML] Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes
…, H Kim, J Lai, K Ragunathan… - Nature …, 2017 - nature.com
Assembly of 30S ribosomes involves the hierarchical addition of ribosomal proteins that
progressively stabilize the folded 16S rRNA. Here, we use three-color single molecule FRET to …
progressively stabilize the folded 16S rRNA. Here, we use three-color single molecule FRET to …