The hypothalamus regulates many innate behaviors, but its development remains poorly
understood. Here, we used single-cell RNA sequencing (RNA-seq) and hybridization chain …

How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the
limb are specified is intensely debated. Early work suggested that cells intrinsically change …

The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its
fundamental role, the cells and signalling pathways that specify this unique region of the central …

How time is measured is an enduring issue in developmental biology. Classical models of
somitogenesis and limb development implicated intrinsic cell cycle clocks, but their existence …

Complex signalling between the apical ectodermal ridge (AER - a thickening of the distal
epithelium) and the mesoderm controls limb patterning along the proximo-distal axis (humerus …

10.7554/eLife.37429.001 The longstanding view of how proliferative outgrowth terminates
following the patterning phase of limb development involves the breakdown of reciprocal …

Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they
are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates …

In the spinal cord, the central canal forms through a poorly understood process termed
dorsal collapse that involves attrition and remodelling of pseudostratified ventricular layer (VL) …

10.7554/eLife.47625.001 A fundamental question is how proliferation and growth are timed
during embryogenesis. Although it has been suggested that the cell cycle could be a timer, …

An intrinsic timing mechanism specifies the positional values of the zeugopod (ie radius/ulna)
and then autopod (ie wrist/digits) segments during limb development. Here, we have …