As malignant tumours develop, they interact intimately with their microenvironment and can
activate autophagy 1 , a catabolic process which provides nutrients during starvation. How …

The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum (ER)
and endosomes, respectively—are connected through contact sites whose numbers …

At the onset of metazoan cell division the nuclear envelope breaks down to enable capture
of chromosomes by the microtubule-containing spindle apparatus 1 . During anaphase, …

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Although lysosomes perform a number of essential cellular functions, damaged lysosomes
represent a potential hazard to the cell. Such lysosomes are therefore engulfed by …

Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery
has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in …

Phosphatidylinositol 3‐phosphate (PtdIns3P) is generated on the cytosolic leaflet of cellular
membranes, primarily by phosphorylation of phosphatidylinositol by class II and class III …

Endocytosis and subsequent membrane traffic through endosomes are cellular processes
that are integral to eukaryotic evolution, and numerous human diseases are associated with …

Translation of mRNA into a polypeptide chain is a highly accurate process. Many prokaryotic
and eukaryotic viruses, however, use leaky termination of translation to optimize their …

During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission
checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells …