PURPOSE Severe (grade 3-4) acute graft-versus-host disease (AGVHD) is a major cause of
death after unrelated-donor (URD) hematopoietic cell transplant (HCT), resulting in …

Organ infiltration by donor T cells is critical to the development of acute graft-versus-host
disease (aGVHD) in recipients after allogeneic hematopoietic stem cell transplant (allo-HCT). …

A critical question facing the field of transplantation is how to control effector T cell (T eff )
activation while preserving regulatory T cell (T reg ) function. Standard calcineurin inhibitor–…

Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem
cell transplant (HCT). However, our understanding of the molecular pathways that cause this …

… Kayla Betz, Kayla Betz … Muna Qayed, Benjamin Watkins, Scott Gillespie, Brandi Bratrude,
Kayla Betz, Sung W. Choi, Jeffrey Davis, Christine Duncan, Roger Giller, Michael Grimley …

Controlling graft-versus-host disease (GVHD) remains a major unmet need in stem cell
transplantation, and new, targeted therapies are being actively developed. CD28-CD80/86 …

As regulatory T cell (Treg) adoptive therapy continues to develop clinically, there is a need
to determine which immunomodulatory agents pair most compatibly with Tregs to enable …

One of the central challenges of transplantation is the development of alloreactivity despite
the use of multiagent immunoprophylaxis. Effective control of this immune suppression–…

In the ABA2 study, the T-cell costimulation blockade agent, abatacept, was safe and
effective in preventing acute graft-versus-host disease (aGVHD) after unrelated-donor …

Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the
question of whether transplantation can eradicate the HIV reservoir. To test this, we here …