An antimicrobial activity of cytolytic T cells mediated by granulysin

…, DA Hanson, R Teitelbaum, P Dewan, KR Niazi… - Science, 1998 - science.org
Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent
mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad …

[HTML][HTML] Deep learning in label-free cell classification

…, A Mahjoubfar, LC Tai, IK Blaby, A Huang, KR Niazi… - Scientific reports, 2016 - nature.com
Label-free cell analysis is essential to personalized genomics, cancer diagnostics, and drug
development as it avoids adverse effects of staining reagents on cellular viability and cell …

Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y. V2 …

G Nelson, O Buzko, P Spilman, K Niazi, S Rabizadeh… - BioRxiv, 2021 - biorxiv.org
Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human
health due to the confirmed greater transmissibility of several of these new strains but, due to …

[HTML][HTML] Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes

…, M Moretti, A Vicario, PC Parodi, M Fabris, KR Niazi… - Scientific reports, 2018 - nature.com
The predominant mechanism by which adipose mesenchymal stem cells (AMSCs)
participate to tissue repair is through a paracrine activity and their communication with the …

Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis

S Stenger, KR Niazi, RL Modlin - The Journal of Immunology, 1998 - journals.aai.org
Intracellular pathogens have developed efficient evasion strategies to survive the defenses
of the host immune system. In this study, we describe a new escape mechanism utilized by …

[PDF][PDF] Molecular interaction of CD1b with lipoglycan antigens

WA Ernst, J Maher, S Cho, KR Niazi, D Chatterjee… - Immunity, 1998 - cell.com
The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T
cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing …

[HTML][HTML] Deep cytometry: deep learning with real-time inference in cell sorting and flow cytometry

Y Li, A Mahjoubfar, CL Chen, KR Niazi, L Pei… - Scientific reports, 2019 - nature.com
Deep learning has achieved spectacular performance in image and speech recognition and
synthesis. It outperforms other machine learning algorithms in problems where large …

[HTML][HTML] An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

…, A Richardson, D Bogunovic, P Spilman, K Niazi… - Scientific Reports, 2021 - nature.com
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their
potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme …

[PDF][PDF] The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens

…, S Stenger, A Lee, DB Moody, RA Rogers, KR Niazi… - Immunity, 1998 - cell.com
CD1b is an antigen-presenting molecule that mediates recognition of bacterial lipid and
glycolipid antigens by specific T cells. We demonstrate that the nine–amino acid cytoplasmic tail …

[HTML][HTML] Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis

…, M Pozzi, F Bassini, M Fabris, KR Niazi… - Mediators of …, 2017 - hindawi.com
The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients
with gonarthrosis comparing two methods of isolation and to investigate their immune …