An antimicrobial activity of cytolytic T cells mediated by granulysin
…, DA Hanson, R Teitelbaum, P Dewan, KR Niazi… - Science, 1998 - science.org
Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent
mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad …
mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad …
[HTML][HTML] Deep learning in label-free cell classification
Label-free cell analysis is essential to personalized genomics, cancer diagnostics, and drug
development as it avoids adverse effects of staining reagents on cellular viability and cell …
development as it avoids adverse effects of staining reagents on cellular viability and cell …
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y. V2 …
G Nelson, O Buzko, P Spilman, K Niazi, S Rabizadeh… - BioRxiv, 2021 - biorxiv.org
Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human
health due to the confirmed greater transmissibility of several of these new strains but, due to …
health due to the confirmed greater transmissibility of several of these new strains but, due to …
[HTML][HTML] Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes
…, M Moretti, A Vicario, PC Parodi, M Fabris, KR Niazi… - Scientific reports, 2018 - nature.com
The predominant mechanism by which adipose mesenchymal stem cells (AMSCs)
participate to tissue repair is through a paracrine activity and their communication with the …
participate to tissue repair is through a paracrine activity and their communication with the …
Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis
S Stenger, KR Niazi, RL Modlin - The Journal of Immunology, 1998 - journals.aai.org
Intracellular pathogens have developed efficient evasion strategies to survive the defenses
of the host immune system. In this study, we describe a new escape mechanism utilized by …
of the host immune system. In this study, we describe a new escape mechanism utilized by …
[PDF][PDF] Molecular interaction of CD1b with lipoglycan antigens
WA Ernst, J Maher, S Cho, KR Niazi, D Chatterjee… - Immunity, 1998 - cell.com
The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T
cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing …
cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing …
[HTML][HTML] Deep cytometry: deep learning with real-time inference in cell sorting and flow cytometry
Deep learning has achieved spectacular performance in image and speech recognition and
synthesis. It outperforms other machine learning algorithms in problems where large …
synthesis. It outperforms other machine learning algorithms in problems where large …
[HTML][HTML] An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
…, A Richardson, D Bogunovic, P Spilman, K Niazi… - Scientific Reports, 2021 - nature.com
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their
potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme …
potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme …
[PDF][PDF] The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens
…, S Stenger, A Lee, DB Moody, RA Rogers, KR Niazi… - Immunity, 1998 - cell.com
CD1b is an antigen-presenting molecule that mediates recognition of bacterial lipid and
glycolipid antigens by specific T cells. We demonstrate that the nine–amino acid cytoplasmic tail …
glycolipid antigens by specific T cells. We demonstrate that the nine–amino acid cytoplasmic tail …
[HTML][HTML] Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis
…, M Pozzi, F Bassini, M Fabris, KR Niazi… - Mediators of …, 2017 - hindawi.com
The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients
with gonarthrosis comparing two methods of isolation and to investigate their immune …
with gonarthrosis comparing two methods of isolation and to investigate their immune …