Targeted gene expression is a powerful approach to study the function of genes and cells in
vivo. In Drosophila, the P element-mediated Gal4-UAS method has been successfully used …

Targeted gene expression by the Gal4‐UAS system is a powerful methodology for analyzing
function of genes and cells in vivo and has been extensively used in genetic studies in …

Cytoplasmic aggregation of TDP-43 characterizes degenerating neurons in most cases of
amyotrophic lateral sclerosis (ALS). Here, we develop an optogenetic TDP-43 variant (opTDP-…

Gene trap and enhancer trap methods using transposon or retrovirus have been recently
described in zebrafish. However, insertional mutants using these methods have not been …

We present a pilot enhancer trap screen using GAL4 to drive expression of upstream
activator sequence (UAS)-linked transgenes in expression patterns dictated by endogenous …

The zebrafish (Danio rerio) is a useful model for genetic studies of vertebrate development.
Its embryos are transparent and develop rapidly outside the mother, making it feasible to …

The molecular genetic mechanisms of sex determination are not known for most vertebrates,
including zebrafish. We identified a mutation in the zebrafish fancl gene that causes …

Background We have developed genetic methods in zebrafish by using the Tol2 transposable
element; namely, transgenesis, gene trapping, enhancer trapping and the Gal4FF-UAS …

In fish, amino acids are food-related important olfactory cues to elicit an attractive response.
However, the neural circuit underlying this olfactory behavior is not fully elucidated. In the …

Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological
activities, including teratogenic and antimyeloma activities. CRBN functions as a …