A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…

Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …

Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response,
inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in …

The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here
we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family…

Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …

Research and development of OCR systems are considered from a historical point of view.
The historical development of commercial systems is included. Both template matching and …

Objective: To evaluate the ability of tocilizumab (a humanised anti-IL-6 receptor antibody)
monotherapy to inhibit progression of structural joint damage in patients with RA. Methods: In a …

Genetic evidence from mutant mice suggests that α 2 -HS glycoprotein/fetuin-A (Ahsg) is a
systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted …