In eukaryotic cells, post-translational histone modifications have an important role in gene
regulation. Starting with early work on histone acetylation 1 , a variety of residue-specific …

Chromatin plays a crucial role in gene regulation, and chromatin immunoprecipitation
followed by sequencing (ChIP–seq) has been the standard technique for examining protein–DNA …

Cellular differentiation is associated with dynamic chromatin remodeling in establishing a
cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and …

Adaptation to mechanical load, leading to enhanced force and power output, is a characteristic
feature of skeletal muscle. Formation of new myonuclei required for efficient muscle …

Nucleosomes are dynamic entities that are repositioned along DNA by chromatin
remodeling processes. A nucleosome repositioned by the switch-sucrose nonfermentable (SWI/SNF) …

Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining
myogenic transcription factors such as MyoD. However, the mechanism of how MyoD …

In multicellular organisms, expression profiling in spatially defined regions is crucial to
elucidate cell interactions and functions. Here, we establish a transcriptome profiling method …

In metazoan cells, only a limited number of mini chromosome maintenance (MCM) complexes
are fired during S phase, while the majority remain dormant. Several methods have been …

Background Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3.
The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has …

10.7554/eLife.48284.001 In overloaded and regenerating muscle, the generation of new
myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two …