[PDF][PDF] A guiding role of the Arabidopsis circadian clock in cell differentiation revealed by time-series single-cell RNA sequencing

K Torii, K Inoue, K Bekki, K Haraguchi, M Kubo… - Cell Reports, 2022 - cell.com
Circadian rhythms and progression of cell differentiation are closely coupled in multicellular
organisms. However, whether establishment of circadian rhythms regulates cell …

Depth of invasion determined by magnetic resonance imaging in tongue cancer can be a predictor of cervical lymph node metastasis

K Haraguchi, D Yoshiga, M Oda, S Tabe… - Oral Surgery, Oral …, 2021 - Elsevier
Objectives We evaluated the relationships between depth of invasion (DOI) of tongue cancer,
as measured with preoperative T1- and T2-weighted magnetic resonance imaging (MRI) …

[HTML][HTML] An inverse QSAR method based on a two-layered model and integer programming

Y Shi, J Zhu, NA Azam, K Haraguchi, L Zhao… - International journal of …, 2021 - mdpi.com
A novel framework for inverse quantitative structure–activity relationships (inverse QSAR)
has recently been proposed and developed using both artificial neural networks and mixed …

The methylation status and expression of human telomerase reverse transcriptase is significantly high in oral carcinogenesis

K Haraguchi, N Yada, S Sato, M Habu, M Hayakawa… - Apmis, 2017 - Wiley Online Library
Telomerase activity is present in most cancers and is tightly regulated by the expression of
human telomerase reverse transcriptase ( hTERT ). Hypermethylation in the promoter region …

Screening for oral cancer using electrochemical telomerase assay

…, M Kodama, K Tomoeda‐Mori, K Haraguchi… - …, 2016 - Wiley Online Library
Electrochemical telomerase assay (ECTA) developed by our group was evaluated in an
oral cancer screening using exfoliated oral cells and tissues obtained from patients of oral …

Oral Cancer Screening Based on Methylation Frequency Detection in hTERT Gene Using Electrochemical Hybridization Assay via a Multi‐electrode Chip Coupled …

K Haraguchi, S Sato, M Habu, N Yada… - …, 2017 - Wiley Online Library
Ferrocenylnaphthalene diimide‐based electrochemical hybridization assay via a multi‐electrode
chip was applied to detect the methylation frequency in the promoter region of human …

A method for molecular design based on linear regression and integer programming

J Zhu, NA Azam, K Haraguchi, L Zhao… - Proceedings of the …, 2022 - dl.acm.org
Recently a novel framework has been proposed for designing the molecular structure of
chemical compounds using both artificial neural networks (ANNs) and mixed integer linear …

An inverse QSAR method based on decision tree and integer programming

K Tanaka, J Zhu, NA Azam, K Haraguchi… - … on Intelligent Computing, 2021 - Springer
Recently a novel framework has been proposed for designing the molecular structure of
chemical compounds using both artificial neural networks (ANNs) and mixed integer linear …

Molecular design based on integer programming and quadratic descriptors in a two-layered model

J Zhu, NA Azam, S Cao, R Ido, K Haraguchi… - arXiv preprint arXiv …, 2022 - arxiv.org
A novel framework has recently been proposed for designing the molecular structure of
chemical compounds with a desired chemical property, where design of novel drugs is an …

Electrochemical telomerase assay for screening for oral cancer

…, S Sato, K Tomoeda-Mori, K Haraguchi… - British Journal of Oral …, 2016 - Elsevier
Telomerase has long been known to be a marker for cancer. We have developed a new
method of detecting it: the electrochemical telomerase assay (ECTA). We have previously …