Objective Complex phenotypes captured on histological slides represent the biological
processes at play in individual cancers, but the link to underlying molecular classification has not …

Purpose: EphA2, a member of the Eph receptor tyrosine kinases family, is an important
regulator of tumor initiation, neovascularization, and metastasis in a wide range of epithelial and …

There are currently no approved targeted therapies for advanced KRAS mutant (KRASMT)
colorectal cancer (CRC). Using a unique systems biology approach, we identified JAK1/2-…

Purpose: Precise mechanism-based gene expression signatures (GES) have been
developed in appropriate in vitro and in vivo model systems, to identify important cancer-related …

Molecular stratification using gene-level transcriptional data has identified subtypes with
distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular subtypes …

Purpose: The DNA damage immune response (DDIR) assay was developed in breast cancer
based on biology associated with deficiencies in homologous recombination and Fanconi …

The recent discovery of oncogenic drivers and subsequent development of novel targeted
strategies has significantly added to the therapeutic armamentarium of anti-cancer therapies. …

The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is
controversial. Here, we identify a cohort of born to be bad early-stage (T1) colorectal tumours, with …

Gremlin1 (GREM1) is a secreted glycoprotein member of the differential screening-selected
gene in aberrant neuroblastoma (DAN) family of bone morphogenetic protein (BMP) …

Objective Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer
(CC), with high relapse rates and limited response to standard adjuvant chemotherapy. …