A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as …

Regulation of the cell cycle is dependent on protein degradation by the ubiquitin–proteasome
system. Two major ubiquitin ligases, the anaphase-promoting complex or cyclosome (APC/…

Artificial intelligence (AI) has contributed substantially to the resolution of a variety of biomedical
problems, including cancer, over the past decade. Deep learning, a subfield of AI that is …

Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated
in a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis …

The chromodomain helicase DNA-binding (CHD) family of enzymes is thought to regulate
gene expression, but their role in the regulation of specific genes has been unclear. Here we …

The cyclin-dependent kinase inhibitor p27 Kip1 is degraded at the G0–G1 transition of the
cell cycle by the ubiquitin–proteasome pathway 1 , 2 . Although the nuclear ubiquitin ligase (…

Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within
a bone marrow niche. Here we show that Foxo3a, a forkhead transcription factor that acts …

Autism spectrum disorder (ASD) comprises a range of neurodevelopmental disorders
characterized by deficits in social interaction and communication as well as by restricted and …

The F‐box protein Skp2 mediates c‐Myc ubiquitylation by binding to the MB2 domain.
However, the turnover of c‐Myc is largely dependent on phosphorylation of threonine‐58 and …

Quiescence is required for the maintenance of hematopoietic stem cells (HSCs). Members
of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p57) have been …