Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative
neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological
malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western
countries, is a heterogeneous disease with variable clinical presentation and evolution 1 , 2 . …