Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric
disorders, normal aging, and neurodegenerative disorders and reduced function of GABA …

Background Neuromorphological changes are consistently reported in the prefrontal cortex
of patients with stress-related disorders and in rodent stress models, but the effects of stress …

Parallel clinical and preclinical research have begun to illuminate the biological basis of
stress-related disorders, including major depression, but translational bridges informing discrete …

Stress-related illnesses such as major depressive and anxiety disorders are characterized
by maladaptive responses to stressful life events. Chronic stress-based animal models have …

Clinical and preclinical studies report that chronic stress induces behavioral deficits as well
as volumetric and synaptic alterations in corticolimbic brain regions including the anterior …

Background Chronic stress is implicated in the development of various psychiatric illnesses
including major depressive disorder. Previous reports suggest that patients with major …

Methods Young (2m, n= 10), middle-age (10m, n= 10) and old (22m, n= 9) mice were
utilized for maturational (young vs. middle-age) and aging-related (middle-age vs. old mice) …

Background The amygdala (AMY) is a key brain region of the limbic system that plays a critical
role in emotion processing and stress response. Functional magnetic resonance imaging (…

Introduction: Chronic stress-related illnesses such as major depressive disorder and post-traumatic
stress disorder share symptomatology, including anxiety, anhedonia, and …

Depression is a leading cause of disabilities around the world, and the underlying mechanisms
involved in its pathophysiology are broad and complex. Exposure to chronic stress is a …