Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for
patterning a variety of structures in animal embryogenesis. During biosynthesis, Hh undergoes …

Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a
critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, …

While there has been steady progress in identifying psychophysiological traits associated
with psychopathy, most of the existing research has been carried out using incarcerated male …

Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for
more than 30 years as potent teratogens capable of inducing cyclopia and other birth defects. …

Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh)
signaling during embryonic development and can initiate or transmit ligand-independent …

THE secreted protein products of the hedgehog (hh) gene family are associated with local
and long-range signalling activities that are responsible for developmental patterning in …

Autocatalytic processing mediated by the carboxy-terminal domain of the hedgehog (hh)
protein precursor (Hh) generates an amino-terminal product that accounts for all known …

Background: The thalamus is a brain region of interest in the study of schizophrenia because
it provides critical input to brain regions such as the prefrontal, cingulate, and temporal …

The ∼25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses
an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog …

Meta-analysis based techniques are emerging as powerful, robust tools for developing
models of connectivity in functional neuroimaging. Here, we apply meta-analytic connectivity …