Notch receptor signaling pathways play an important role not only in normal breast development
but also in breast cancer development and progression. We assessed the role of Notch …

A role for Notch signaling in human breast cancer has been suggested by both the development
of adenocarcinomas in the murine mammary gland following pathway activation and …

Background The epidermal growth factor receptor (EGFR) and Notch signaling pathways
have been implicated in self-renewal of normal breast stem cells. We investigated the …

Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic
development, and aberrant activation of the canonical Wnt/β-catenin pathway is one of the most …

The establishment and stability of cell fates during development depend on the integration
of multiple signals, which ultimately modulate specific patterns of gene expression. While …

Secreted signaling proteins of the Wnt family are known to regulate a diverse range of
developmental processes, and their signaling pathway through β-catenin is frequently activated in …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic
cells and is commonly thought to translocate to mitochondria following an apoptotic stimulus. …

During development, signalling by members of the Notch family of cell surface receptors
plays a widespread role in the assignation of cell fates within the process of lateral inhibition. …

The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways
that control cell-fate decisions during animal development (Pires-daSilva and Sommer in …