The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels
and chemicals, and it is also provides a platform for the production of many heterologous …

Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew
tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here, we …

Highlights ▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell factories …

Yeast-based biosensing (YBB) is an exciting research area, as many studies have demonstrated
the use of yeasts to accurately detect specific molecules. Biosensors incorporating …

Engineering robust microbes for the biotech industry typically requires high-level, genetically
stable expression of heterologous genes and pathways. Although plasmids have been …

Background In spite of its great promise, metabolomics has proven difficult to execute in an
untargeted and generalizable manner. Liquid chromatography–mass spectrometry (LC–MS) …

Yeast Saccharomyces cerevisiae has become an attractive cell factory for production of
commodity and speciality chemicals and proteins, such as industrial enzymes and …

Deep mutational scanning is a foundational tool for addressing the functional consequences
of large numbers of mutants, but a more efficient and accessible method for construction of …

Background The protein secretory pathway must process a wide assortment of native proteins
for eukaryotic cells to function. As well, recombinant protein secretion is used extensively …

Engineering industrial microbes has been hampered by incomplete knowledge of cell biology.
Thus an iterative engineering cycle of modeling, implementation, and analysis has been …