A complex choreography of cell movements shapes the vertebrate eye

KM Kwan, H Otsuna, H Kidokoro, KR Carney… - …, 2012 - journals.biologists.com
Optic cup morphogenesis (OCM) generates the basic structure of the vertebrate eye.
Although it is commonly depicted as a series of epithelial sheet folding events, this does not …

Nonthreaded Isomers of Sungsanpin and Ulleungdin Lasso Peptides Inhibit H1299 Cancer Cell Migration

…, A Ghorai, H Kim, MC Mifflin, KR Carney… - ACS Chemical …, 2023 - ACS Publications
Lasso peptides are a structurally distinct class of biologically active natural products defined
by their short sequences with impressively interlocked tertiary structures. Their characteristic …

[PDF][PDF] Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis

HB Gordon, S Lusk, KR Carney, EO Wirick… - …, 2018 - journals.biologists.com
Establishment of precise three-dimensional tissue structure is vital for organ function. In the
visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood …

[HTML][HTML] p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration

…, A Elliott, BD Mueller, Y Kim, KR Carney… - Journal of Biological …, 2019 - ASBMB
Cell migration is essential to embryonic development, wound healing, and cancer cell
dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of the …

Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism

KR Carney, AM Khan, S Stam… - Molecular biology of …, 2023 - Am Soc Cell Biol
Directional cell migration is driven by the conversion of oscillating edge motion into lasting
periods of leading edge protrusion. Actin polymerization against the membrane and …

[HTML][HTML] LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation

KR Carney, CD Bryan, HB Gordon, KM Kwan - Developmental biology, 2020 - Elsevier
Epithelial morphogenesis, a fundamental aspect of development, generates 3-dimensional
tissue structures crucial for organ function. Underlying morphogenetic mechanisms are, in …

[HTML][HTML] Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis

RG Zitnay, MR Herron, KR Carney… - PLoS Computational …, 2022 - journals.plos.org
Early lung cancer lesions develop within a unique microenvironment that undergoes constant
cyclic stretch from respiration. While tumor stiffening is an established driver of tumor …

Fascin structural plasticity mediates flexible actin bundle construction

R Gong, MJ Reynolds, KR Carney, K Hamilton… - bioRxiv, 2024 - biorxiv.org
Fascin crosslinks actin filaments (F-actin) into bundles that support tubular membrane protrusions
including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration …

Nascent adhesions differentially regulate lamellipodium velocity and persistence

KR Carney, AM Khan, SC Samson, N Mittal, SJ Han… - bioRxiv, 2021 - biorxiv.org
Cell migration is essential to physiological and pathological biology. Migration is driven by
the motion of a leading edge, in which actin polymerization pushes against the edge and …

[PDF][PDF] Hyperfine Resolution of Fluorescent DNA Melting

KR Carney, CT Wittwer - Biopolymers - dna-utah.org
Materials and Methods: A diagram of our custom prototype melting instrument is shown in
Figure 1, and a cross-section of the optical configuration is shown in Figure 2. This instrument …