A complex choreography of cell movements shapes the vertebrate eye
Optic cup morphogenesis (OCM) generates the basic structure of the vertebrate eye.
Although it is commonly depicted as a series of epithelial sheet folding events, this does not …
Although it is commonly depicted as a series of epithelial sheet folding events, this does not …
Nonthreaded Isomers of Sungsanpin and Ulleungdin Lasso Peptides Inhibit H1299 Cancer Cell Migration
…, A Ghorai, H Kim, MC Mifflin, KR Carney… - ACS Chemical …, 2023 - ACS Publications
Lasso peptides are a structurally distinct class of biologically active natural products defined
by their short sequences with impressively interlocked tertiary structures. Their characteristic …
by their short sequences with impressively interlocked tertiary structures. Their characteristic …
[PDF][PDF] Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis
HB Gordon, S Lusk, KR Carney, EO Wirick… - …, 2018 - journals.biologists.com
Establishment of precise three-dimensional tissue structure is vital for organ function. In the
visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood …
visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood …
[HTML][HTML] p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
…, A Elliott, BD Mueller, Y Kim, KR Carney… - Journal of Biological …, 2019 - ASBMB
Cell migration is essential to embryonic development, wound healing, and cancer cell
dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of the …
dissemination. Cells move via leading-edge protrusion, substrate adhesion, and retraction of the …
Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism
Directional cell migration is driven by the conversion of oscillating edge motion into lasting
periods of leading edge protrusion. Actin polymerization against the membrane and …
periods of leading edge protrusion. Actin polymerization against the membrane and …
[HTML][HTML] LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation
Epithelial morphogenesis, a fundamental aspect of development, generates 3-dimensional
tissue structures crucial for organ function. Underlying morphogenetic mechanisms are, in …
tissue structures crucial for organ function. Underlying morphogenetic mechanisms are, in …
[HTML][HTML] Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis
RG Zitnay, MR Herron, KR Carney… - PLoS Computational …, 2022 - journals.plos.org
Early lung cancer lesions develop within a unique microenvironment that undergoes constant
cyclic stretch from respiration. While tumor stiffening is an established driver of tumor …
cyclic stretch from respiration. While tumor stiffening is an established driver of tumor …
Fascin structural plasticity mediates flexible actin bundle construction
R Gong, MJ Reynolds, KR Carney, K Hamilton… - bioRxiv, 2024 - biorxiv.org
Fascin crosslinks actin filaments (F-actin) into bundles that support tubular membrane protrusions
including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration …
including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration …
Nascent adhesions differentially regulate lamellipodium velocity and persistence
Cell migration is essential to physiological and pathological biology. Migration is driven by
the motion of a leading edge, in which actin polymerization pushes against the edge and …
the motion of a leading edge, in which actin polymerization pushes against the edge and …
[PDF][PDF] Hyperfine Resolution of Fluorescent DNA Melting
KR Carney, CT Wittwer - Biopolymers - dna-utah.org
Materials and Methods: A diagram of our custom prototype melting instrument is shown in
Figure 1, and a cross-section of the optical configuration is shown in Figure 2. This instrument …
Figure 1, and a cross-section of the optical configuration is shown in Figure 2. This instrument …