Developmental events in the life-cycle of the sleeping sickness parasite comprise integrated
changes in cell morphology, metabolism, gene expression and signalling pathways. In each …

Vector-borne parasites cause major human diseases of the developing world, including
malaria, human African trypanosomiasis, Chagas disease, leishmaniasis, filariasis, and …

African trypanosomes are responsible for important diseases of humans and animals in sub-Saharan
Africa. The best-studied species is Trypanosoma brucei, which is characterized by …

African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis.
They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for …

Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology,
including cell structure and morphology, organelle positioning, cell division and protein …

Microbial pathogens use environmental cues to trigger the developmental events needed to
infect mammalian hosts or transmit to disease vectors. The parasites causing African …

Preventing the transmission of African trypanosomes between mammalian hosts has been
one of the most effective mechanisms to date for the control of these important parasites. …

In the mammalian bloodstream, the sleeping sickness parasite Trypanosoma brucei is held
poised for transmission by the activity of a tyrosine phosphatase, TbPTP1. This prevents …

In trypanosomes, the generation of monocistronic mRNAs from polycistronic precursors is
achieved via RNA processing, namely trans-splicing of the spliced leader sequence at the 5' …

A 10 amino acid sequence from the immunologically well characterized major structural protein
of the Saccharomyces cerevisiae Ty1 virus-like particle was developed as an epitope tag…